|
|
|
| Clinical effect of Risperidone combined with Citalopram regimen in the treatment of negative symptoms of schizophrenia |
| RUAN Jian-hong |
| The Third Department of Clinical Medicine,Mental Health Centre of Inner Mongolia Autonomous Region,Hohhot 010010,China |
|
|
|
|
Abstract Objective To explore the clinical effect of Risperidone combined with Citalopram regimen in the treatment of negative symptoms of schizophrenia.Methods A total of 80 patients with negative symptoms of schizophrenia from the Third Department of Clinical Medicine in Mental Health Center of Inner Mongolia Autonomous Region from August 2016 to December 2018 were selected as the research subjects.They were divided into Risperidone treatment group(40 cases)and combined treatment group(40 cases)by random number table method.Patients in the Risperidone treatment group were treated with Risperidone,and patients in the combined treatment group were treated with Citalopram combined with Risperidone.The total effective rate,drug onset time and length of stay were compared between the two groups;positive symptom score,negative symptom score,general mental score,total score of positive and negative symptom scale before and after treatment were compared between the two groups;the total incidence of side effect of drugs was compared between the two groups.Results The total effective rate in the combined treatment group was higher than that in the Risperidone treatment group,and the difference was statistically significant(P＜0.05).Before treatment,there were no statistically significant differences in the positive symptom score,negative symptom score,general mental score,the total score of the positive and negative symptom scales between the two groups (P＞0.05).After treatment,the positive symptom score,negative symptom score,general mental score,the total score of positive and negative symptom scales in the combined treatment group were lower than those in the Risperidone treatment group,and the differences were statistically significant(P＜0.05).The drug onset time and length of stay in the combined treatment group were shorter than those in the Risperidone treatment group,and the differences were statistically significant(P＜0.05).There was no statistically significant difference in the total incidence of side effect between the two groups (P＞0.05).Conclusion Citalopram combined with Risperidone is effective in the patients with negative symptoms of schizophrenia,which can effectively improve the patients′negative symptoms,and the onset time is shorter for combined medication,with higher safety.
|
|
|
|
|
|
| [1] |
刘少华，朱琳，刘旺林，等.草酸艾司西酞普兰片合并利培酮治疗精神分裂症阴性症状对照研究[J].江西医药，2020，55（12）：1787-1789.
|
| [2] |
裘建萍，班春霞，沈凯，等.艾司西酞普兰联合利培酮治疗精神分裂症阴性症状的疗效[J].中国健康心理学杂志，2020，28（10）：1445-1448.
|
| [3] |
程思，李娟，刘书明，等.阿立哌唑、艾司西酞普兰对精神分裂症阴性症状的效果[J].中国继续医学教育，2020，12（20）：159-161.
|
| [4] |
梁玉霞，宋丽，吴俊红.艾司西酞普兰联合经颅磁刺激治疗难治性精神分裂症患者阴性症状的效果[J].中国实用医刊，2020，47（10）：64-67.
|
| [5] |
王丽娜.齐拉西酮联合氢溴酸西酞普兰治疗伴发抑郁症状精神分裂症患者的疗效[J].中国实用医药，2019，14（5）：142-143.
|
| [6] |
杨筱慧.附加艾司西酞普兰治疗对男性精神分裂症认知损害改善的分析[J].中外医疗，2018，37（14）：115-116，119.
|
| [7] |
张岩滨.哌罗匹隆联合艾司西酞普兰治疗阴性症状为主的精神分裂症临床观察[J].中国实用神经疾病杂志，2018，21（8）：867-869.
|
| [8] |
李烽.阴性症状为主的精神分裂症患者联用氨磺必利、艾司西酞普兰治疗的效果[J].临床医药文献电子杂志，2017，4（45）：8862-8863.
|
| [9] |
肖剑文，黄丽，刘庆华.利培酮联合艾司西酞普兰对精神分裂症患者个人和社会功能的影响研究[J].临床合理用药杂志，2016，9（15）：35-37.
|
| [10] |
王德燧，邓小豆.联用艾司西酞普兰和奋乃静对合并抑郁症的老年精神分裂症患者进行治疗的效果探析[J].当代医药论丛，2015，13（21）：211-212.
|
| [11] |
赵长苓，苟汝红，徐德会，等.齐拉西酮联合西酞普兰治疗精神分裂症阴性症状的临床研究[J].河北医药，2015，37（13）：1982-1984.
|
| [12] |
李小新.氨磺必利联合西酞普兰治疗精神分裂症阴性症状的疗效观察[J].当代医学，2014，20（35）：131-132.
|
| [13] |
段丽娟，陈红昊，刘媛媛.齐拉西酮合并艾司西酞普兰治疗以阴性症状为主的精神分裂症对照研究[J].精神医学杂志，2014，27（6）：417-420.
|
| [14] |
孙晓丹，周升宝，田月礼，等.奥氮平合并艾司西酞普兰治疗精神分裂症阴性症状[J].中国健康心理学杂志，2014，22（8）：1135-1137.
|
| [15] |
严冬梅，周丽芳，马休玉，等.帕利哌酮联合艾司西酞普兰对精神分裂症患者认知功能及阴性症状的影响[J].中国慢性病预防与控制，2014，22（4）：481-483.
|
|
|
|
