不同剂量瑞马唑仑用于全身麻醉诱导的临床效果

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Abstract Objective To investigate the clinical effect of different doses of Remazolam on induction of general anesthesia. Methods A total of 100 patients undergoing elective tracheal intubation under general anesthesia admitted to the First People′s Hospital of Lianyungang from January to March 2021 were selected as the research subjects, and they were divided into group A (25 cases), group B (25 cases), group C (25 cases) and group D (25 cases) according to random number table method. Sufentanil and Cisatracurium were used for induction of general anesthesia in all four groups. On this basis, group A was treated with 2 mg/kg Propofol, group B was treated with 0.2 mg/kg Remazolam,group C was treated with 0.3 mg/kg Remazolam, and group D was treated with 0.4 mg/kg Remazolam. The mean arterial pressure (MAP) and heart rate (HR) of the four groups were compared at entry into the operating room (T0), bispectral index of electroencephalogram after drug administration (BIS) ≤60 (T1) and endotracheal intubation (T2). The onset time and times of additional administration were compared among the four groups. The incidence of adverse reactions in four groups was compared. Intraoperative awareness assessment was performed 1 day after surgery. Results At T1, MAP and HR of the four groups were lower than those of the same group at T0, the difference was statistically significant (P＜0.05), but there was no significant difference between MAP and HR of the four groups at T0, T1 and T2 (P＞0.05). The onset time of drugs in groups B, C and D was longer than that in group A, group B was longer than that in groups C and D, and group C was longer than that in group D, with statistical significance (P＜0.05). The frequency of additional administration in group B was higher than that in groups A, C and D, and the difference was statistically significant (P＜0.008). The total incidence of adverse reaction in group B, C and D was lower than that in group A, and the differences were statistically significant (P＜0.008). None of the patients in the four groups had any known intraoperative occurrence. Conclusion Remazolam can be used effectively and safely in induction of general anesthesia with tracheal intubation, and the effect and safety of 0.3 mg/kg is better.

Key words： Remazolam Propofol Anesthesia induction Trachea cannula Bispectral index

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	LIU Dong-zhi
	SUN Cheng-liang
	ZHAO Zhi-bin

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LIU Dong-zhi,SUN Cheng-liang,ZHAO Zhi-bin. Clinical effects of different doses of Remazolam in induction of general anesthesia[J]. 中国当代医药, 2021, 28(28): 122-125.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I28/122

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