不同类型抑郁障碍患者静息态功能磁共振成像下前扣带回功能变化及鉴别诊断价值

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Abstract Objective To investigate the changes of anterior cingulate function in patients with different types of depressive disorders under resting-state functional magnetic resonance imaging (fMRI), and its differential diagnosis value. Methods The clinical data of 50 patients with unipolar depression (UD) and bipolar depression (BD) from the Affiliated Brain Hospital of Guangzhou Medical University were retrospectively analyzed. Meanwhile, a total of 50 healthy individuals were selected as the control group. The three groups all received resting-state functional magnetic resonance imaging scan, and the functional connectivity characteristics of anterior cingulate were compared among the three groups. Results The connectivity between left anterior cingulate and left triangle inferior frontal gyrus as well as left top-inferior angular gyrus, and the connectivity between right anterior cingulate and left triangle inferior frontal gyrus in UD group were stronger than those in the control group, the differences were statistically significant (P＜0.05). The connectivity between left anterior cingulate and right middle temporal gyrus, the connectivity between right anterior cingulate and left central posterior gyrus, right superior temporal gyrus, and right middle temporal gyrus in BD group were weaker than those in the control group, the differences were statistically significant (P＜0.05). The connectivity between left anterior cingulate and left triangle inferior frontal gyrus as well as right triangle inferior frontal gyrus, the connectivity between right anterior cingulate and left triangle inferior frontal gyrus, left top-inferior angular gyrus, and right top-inferior angular gyrus in UD group were stronger than those in BD group, the differences were statistically significant (P＜0.05). Conclusion Compared with normal people, there are obvious changes of anterior cingulate function in patients with UD and BD in resting state. Patients with UD mainly manifest as enhanced functional connectivity of anterior cingulate, and patients with BD have weakened functional connectivity of anterior cingulate, which provides reference for distinguishing UD from BD and helps to guide treatment and medication of physicians.

Key words： Unipolar depression Bipolar depression;Resting-state functional magnetic resonance Cingulate gyrus

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	Articles by authors
	GUAN Li-jie
	ZOU Wen-jin
	ZHANG Ruo-xi
	LAO Guo-hui

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GUAN Li-jie,ZOU Wen-jin,ZHANG Ruo-xi, et al. Changes of anterior cingulate function in patients with different types of depressive disorders under resting-state functional magnetic resonance imaging and its differential diagnosis value[J]. 中国当代医药, 2021, 28(28): 92-95.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I28/92

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