免疫法与化学法粪便隐血试验在大肠癌早期筛查中的应用比较

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Abstract Objective To compare the effect of immune and chemical fecal occult blood tests (OBT) in the early screening of colorectal cancer.Methods A total of 50 suspected early colorectal cancer patients in Nanchang Hongdu Hospital of Traditional Chinese Medicine from May 2018 to January 2020 were selected as the research objects.The feces of the 50 patients were collected, and immune and chemical OBT tests were performed.The pathological results of biopsy were used as the "gold standard" for diagnosis.The diagnostic efficacy of immune and chemical OBT for early screening of colorectal cancer was compared.The immunofecal occult blood test (iFOBT) values of colorectal cancer patients with different prognosis were compared, and the receiver operating characteristic (ROC) curves were drawn to analyze the iFOBT values to predict the prognosis of colorectal cancer patients.Results Among the 50 suspected cases of early colorectal cancer, there were 30 cases (60.00%) of early colorectal cancer, 12 cases (24.00%) of colonic polyp and 8 cases (16.00%) of inflammatory bowel disease were confirmed by biopsy and pathological examination.The sensitivity,specificity, accuracy, positive predictive value and negative predictive value (96.67%, 90.00%, 94.00%, 93.55%,94.74%) of immune OBT in the diagnosis of colorectal cancer were higher than those of chemical OBT (70.00%,55.00%, 64.00%, 70.00%, 52.38%), and the differences were statistically significant (P＜0.05).The IFOBT value of patients with poor prognosis was higher than that of patients with good prognosis, and the difference was statistically significant (P＜0.05).The area under the ROC curve (AUC) of the iFOBT value was＞0.7 in diagnosis of colorectal cancer.The iFOBT value had a high value in predicting the prognosis of colorectal cancer, and the best predictive value could be reached when the optimal threshold was reached.Conclusion Compared with chemical OBT, immune OBT has higher clinical value and better screening effect in the early screening of colorectal cancer, and the prognosis of colorectal cancer can be predicted by the iFOBT value.

Key words： Colorectal cancer Early screening Fecal occult blood test Immune method Chemical method

Received: 17 December 2020

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