舍雷肽酶肠溶片联合鼻内糖皮质激素对慢性鼻-鼻窦炎术后黏膜恢复的疗效观察

Abstract
Figure/Table
References (19)
Related Citation (2)

Download: PDF (0 KB) HTML (36 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the clinical effect of Serrenopeptidase Enteric-coated Tablets combined with intranasal Glucocorticoid on nasal mucosal recovery after encloscopic sinus surgery.Methods A total of 44 patients with chronic rhinosinusitis treated in Luoding People′s Hospital from January 2017 to October 2019 were selected as the research subjects,and were divided into observation group(22 cases)and control group(22 cases)according to random number table method.Functional nasal endoscopic surgery was performed in both groups.The control group was given Momethasone Furoate Nasal Spray after nasal spray,and the observation group was given Serrenopeptidase Entericcoated Tablets on the basis of the control group orally.Clinical symptom scores and Lund-Kennedy scores were compared between the two groups before and after intervention.Results There was no significant difference in clinical symptom scores between the two groups before treatment(P>0.05).After treatment,the scores of nasal obstruction,runny nose,headache and decreased olfaction in the two groups were lower than before,and the scores of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).There was no significant difference in Lund-Kennedy scores between the two groups before treatment(P>0.05).After treatment,Lund-Kennedy scores in both groups were lower than before,and Lund-Kennedy scores in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion In patients with chronic sinusitis,Serrapeptase Enteric-coated Tablets orally combined with intranasal Glucocorticoid Nasal Spray can enhance the mucosal swelling reduction and promote the recovery of nasal cavity and sinus mucosa,which has good clinical application value.

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	OU Jing
	ZHU Xian-wen▲

Cite this article:

OU Jing,ZHU Xian-wen▲. Effect of Serrapeptase Enteric-coated Tablets combined with intranasal Glucocorticoid on nasal mucosal recovery after encloscopic sinus surgery[J]. 中国当代医药, 2021, 28(18): 26-29.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I18/26

[1]	孔维佳，周梁，许庚，等.耳鼻咽喉头颈外科学[M].北京：人民卫生出版社，2005：460.
[2]	张勇.舍雷肽酶肠溶片对慢性鼻窦炎疾病肿胀的疗效及安全性评估[J].海峡药学，2019，31（7）：140-141.
[3]	刘奕，林松杉，章禾，等.舍雷肽酶预防下颌阻生智齿拔除术后肿胀的效果观察[J].吉林医学，2012，55（10）：976-977.
[4]	杨丹芬.舍雷肽酶肠溶片联合噻托溴铵治疗支气管扩张症的疗效观察[J].现代药物与临床，2016，31（12）：1946-1949.
[5]	中华耳鼻咽喉头颈外科杂志编委会，中华医学会耳鼻咽喉头颈外科学分会鼻科学组.慢性鼻-鼻窦炎诊断和治疗指南[J].中国临床医生，2010，38（4）：73-74.
[6]	Lund VJ，Kennedy DW．Staging for rhinosinusitis[J].Otolaryngol Head Neck Surg，1997，117（3）：S35.
[7]	陈嵘，曾薇，马敬君.鼻内镜手术治疗慢性鼻窦炎伴鼻息肉的临床疗效及对生活质量的影响[J].中国现代医生，2019，57（29）：59-61.
[8]	陈国锋，王振英，吴海导.鼻内镜手术联合药物治疗慢性鼻-鼻窦炎的临床效果[J].中国当代医药，2019，26（23）：97-101.
[9]	茅金金.鼻内镜术后鼻喷激素治疗慢性鼻窦炎鼻息肉的效果探讨[J].中国医药科学，2020，10（6）：284-287.
[10]	单晓英.糠酸莫米松鼻喷雾剂应用在小儿鼻窦炎治疗中的临床疗效分析[J].中国医学文摘（耳鼻咽喉科学），2020，35（5）：315-318.
[11]	陈开雄，赵云峰，蔡兰玉，等.鼻内镜术后局部糖皮质激素治疗慢性鼻窦炎疗效观察[J].吉林医学，2016，37（9）：2137-2138.
[12]	李娟，程杰，何艳.鼻腔冲洗联合糠酸莫米松鼻喷雾剂治疗变应性鼻炎的疗效观察[J].重庆医学，2016，45（25）：3506-3507.
[13]	顾有守.全身应用糖皮质激素的不良反应及防治对策[J].皮肤病与性病，2016，38（1）：16-18.
[14]	温文胜，黄光武，武鸿泉，等.沙雷肽酶对慢性鼻窦炎鼻窦黏膜中纤维蛋白分解酶活性的影响[J].广西医科大学学报，2002，19（6）：827-828.
[15]	李晓华，詹志荣，孙建设，等.布地奈德对不伴鼻息肉的慢性鼻鼻窦炎术后鼻黏膜细胞外基质的影响[J].中国耳鼻咽喉头颈外科，2014，21（10）：546-549.
[16]	Watelet JB，Demetter P，Claeys C，et al.Neutrophil-derived metalloproteinase-9 predicts healing quality after sinus surgery[J].Laryngoscope，2005，115（1）：56-61.
[17]	范道圣，王登，熊汉忠.舍雷肽酶肠溶片联合复方异丙托溴铵治疗慢性阻塞性肺疾病急性加重期疗效观察[J].中国药师，2020，23（10）：1963-1966.
[18]	殷凯生，付完珍，何礼贤，等.舍雷肽酶肠溶片黏痰溶解与祛痰疗效的多中心随机双盲对照临床研究[J].中国新药与临床杂志，2006，25（10）：737-740.
[19]	李文峰，范华，邝军，等.国产与进口舍雷肽酶肠溶片治疗小儿支气管扩张的效果比较[J].广东医学，2016，37（9）：1379-1382.