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| Correlation analysis between the expression of procalcitonin, interleukin-6,C-reactive protein and pulmonary function in patients with chronic bronchitis |
| SONG Qing-jun XIAO Tao |
| Department of Respiratory, Changqing District People′s Hospital of Ji′nan City, Shandong Province, Ji′nan 250300,China |
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Abstract Objective To investigate the relationship between the expression of procalcitonin (PCT), interleukin 6 (IL-6),C-reactive protein (CRP) and pulmonary function in patients with chronic bronchitis. Methods Clinical data of 79 patients with chronic bronchitis in Changqing District People′s Hospital of Jinan City from October 2018 to October 2020 were retrospectively analyzed. According to the progress of the disease, they were divided into the acute exacerbation group (41 cases) and the remission group (38 cases). A total of 30 healthy people in the same period were selected as the control group. The serum PCT, IL-6, CRP levels and related pulmonary function indexes such as the forced vital capacity (FVC), forced expiratory volume in the first second (FEV1) and maximum ventilation volume (MVV) were compared among the three groups, and the correlation analysis was carried out. Results There were statistically significant differences in the levels of PCT, IL-6 and CRP among the three groups (P＜0.05). The levels of PCT, IL-6 and CRP in the acute exacerbation group and the remission group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The levels of PCT, IL-6 and CRP in the acute exacerbation group were higher than those in the remission group, and the differences were statistically significant (P＜0.05). There were statistically significant differences in the FVC, FEV1 MVV among the three groups (P＜0.05). The levels of FVC, FEV1and MVV in the acute exacerbation group and the remission group were lower than those in the control group, and the differences were statistically significant (P＜0.05). The levels of FVC, FEV1 and MVV in the acute exacerbation group were lower than those in the remission group, and the differences were statistically significant (P＜0.05). Pearson correlation analysis showed that the levels of PCT,IL-6 and CRP were negatively correlated with FVC,FEV1 and MVV(r=-0.693,-0.724,-0.738, P＜0.05). Conclusion The levels of PCT, IL-6 and CRP in patients with chronic bronchitis are correlated with FVC, FEV1 and MVV, which can provide reference for clinical treatment and disease monitoring.
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| [1] |
张炜刚.左氧氟沙星氯化钠注射液联合阿奇霉素治疗慢性支气管炎的效果观察[J].中国药物与临床，2020，20（7）：1152-1154.
|
| [2] |
陆燕.盐酸氨溴索注射液联合溴己新对慢性支气管炎患者血清炎症因子的影响[J].中外医学研究，2019，17（28）：168-169.
|
| [3] |
王辰，王建安.内科学[M].3 版.北京：人民卫生出版社，2015：31.
|
| [4] |
葛均波，徐永健，王辰.内科学[M].9 版.北京：人民卫生出版社，2018：20.
|
| [5] |
刘菊芬，陈妍妍，权淑贞.细菌感染性肺炎患儿血清IL-6、PCT 及hs-CRP 水平与肺功能的相关性[J].中国实用医刊，2020，47（24）：84-86.
|
| [6] |
付明倜，王月芹.乌司他丁联合比阿培南对老年重症肺炎患者肺功能、血气分析、炎性因子及血清CD40L 和VACM-1 表达的影响[J].中国老年学杂志，2020，40（12）：2552-2555.
|
| [7] |
昌仲勇，杨为斌，王强，等.血清hs-CRP、IL-6、PCT 对新型冠状病毒肺炎患者的诊断及预后评估的临床意义[J].现代药物与临床，2020，35（3）：417-420.
|
| [8] |
汪辰姬.美罗培南对重症下呼吸道感染患者血清炎性因子水平和肺功能改善的影响[J].抗感染药学，2020，17（9）：1382-1385.
|
| [9] |
陈玉虎.基层医护人员慢性支气管炎健康素养调查及影响因素研究[D].乌鲁木齐：新疆医科大学，2020.
|
| [10] |
任晓磊.基于代谢组学的慢性支气管炎发病机理及岩白菜素作用机制研究[D].北京：北京中医药大学，2016.
|
| [11] |
张艳琳，熊昊.回顾性分析PCT 和高灵敏度C-反应蛋白在确诊老人肺部感染的价值[J].口岸卫生控制，2019，24（2）：31-33，36.
|
| [12] |
闫圣涛，何秀燕，孙力超，等.降钙素原在血流感染病原学诊断中的价值[J].中华急诊医学杂志，2021，30（4）：426-431.
|
| [13] |
姜晓月，张文静，查才军，等.C 反应蛋白单体在炎症-血栓网络中作用的研究进展[J].国际免疫学杂志，2021，44（3）：351-354.
|
| [14] |
彭敏颜，姜朝新，杨璇.血清降钙素原、白细胞介素6 和C 反应蛋白在脓毒血症和全身炎症反应综合征鉴别诊断中的意义[J].临床检验杂志（电子版），2020，9（2）：121-122.
|
| [15] |
何添标，黎艳聪，袁健志.AECOPD 患者血清PCT、IL-6、CRP 水平与肺通气功能的相关性研究[J].海南医学院学报，2019，25（6）：447-450.
|
| [16] |
李莉，孙颖颖，王怡璐，等.miR-125b 在急性加重期慢性阻塞性肺疾病患者血浆中的表达及与肺功能和炎症细胞因子的关系[J].现代生物医学进展，2020，20（5）：944-948.
|
| [17] |
梁志岐，苗少民.盐酸氨溴索与多索茶碱联合治疗慢性支气管炎急性发作的临床效果[J].临床医学研究与实践，2020，5（10）：39-41.
|
| [18] |
刘颖慧.射干麻黄汤对慢性支气管炎急性发作老年患者血清IL-6、PCT、hs-CRP 的影响[J].中医药临床杂志，2019，31（6）：1108-1110.
|
|
|
|
