血站无偿献血中机采血小板造成冲红原因分析及影响因素研究

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Abstract Objective To explore the reasons and related influence factors of red blood cell spill-out caused by apheresis platelets (PLT) in the voluntary blood donation at blood stations. Methods A total of 1532 voluntary blood donors who donated PLT at the blood station in Ji′ning Blood Center, Shandong Province from January 2020 to January 2021 were selected as the research subjects. The status of RBC spill-out caused by apheresis PLT was counted, and the related influence factors of red blood cell spill-out caused by apheresis PLT were analyzed. Results Among the 1532 cases of voluntary blood donors, a total of 60 cases had red blood cell spill-out phenomenon, and the red blood cell spill-out rate of apheresis PLT was 3.92%. Single factor analysis showed that the differences of deposited (HCT),count of red blood cells (RBC), the average amount of hemoglobin (MCH), average red blood cell volume (MCV), mean hemoglobin concentration (MCHC) level, blood fat ratio, stress ratio and supplies operating errors of the two groups were statistically significant (P＜0.05). Multivariate analysis showed that HCT increased (β=2.735, OR=9.784, 95%CI=3.272-18.095), RBC increased (β=2.262, OR=5.611, 95%CI=1.818-12.487), MCH decreased (β=2.097, OR=8.143,95%CI=3.178-16.205), MCV decreased (β=2.219, OR=6.053, 95%CI=1.028-9.099), MCHC decreased (β=3.797, OR=34.571, 95%CI=14.47-107.231), fat blood (β=2.856, OR=23.063, 95%CI=10.028-69.033), mental stress (β=2.436, OR=17.053, 95%CI=9.028-57.059), consumable operation error (β=2.052, OR=7.053, 95%CI=2.028-15.091) were risk factors of the red blood cell spill-out of apheresis PLT (P＜0.05). Conclusion The red blood cell spill-out caused by apheresis PLT in the voluntary blood donation of blood stations is closely related to the increase of HCT, the increase of red blood cell, the decrease of MCH, MCV and MCHC, fat blood in the blood of patients, mental stress, and consumable operation error. In clinical practice, targeted measures should be taken to eliminate the influence factors so as to reduce red blood cell spill-out caused by apheresis PLT.

Key words： Voluntary blood donation;Apheresis platelets;Red blood cell spill-out phenomenon Transfusion safety;Influence factors

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	WANG Li-hua

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WANG Li-hua. Analysis of the causes and influence factors of red blood cell spill-out caused by apheresis platelets in the voluntary blood donation at blood station[J]. 中国当代医药, 2021, 28(28): 72-74-78.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I28/72

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