Objective To explore the clinical efficacy of the"Jin San Needle"combined with early start Denver model(ESDM)in children with global developmental delay(GDD)and autistic spectrum disorder(ASD).Methods A total of 123 children with GDD and ASD treated in Ganzhou Maternal and Child Health Hospital from April to August 2023 were selected as the study objects,and they were divided into routine rehabilitation group,ESDM group and"Jin San Needle"+ESDM group according to random number table method,with 41 cases each.The clinical efficacy,Gesell development diagnosis scale(GDDS)score,autism behavior checklist(ABC)score,childhood autism rating scale (CARS) score and adverse reactions of the three groups were compared.Results The total clinical effective rate of GDD with ASD in "Jin San Needle"+ESDM group was higher than that in ESDM group and conventional rehabilitation group,the difference was statistically significant(P＜0.017).After treatment,the scores of gross motor,adaptation,fine motor,personal-social,language and GDDS in "Jin San Needle"+ESDM group were higher than those in ESDM group and conventional rehabilitation group,and the differences were statistically significant(P＜0.05).The AD,PS scores and GDDS scores in ESDM group were higher than those in conventional rehabilitation group,and the differences were statistically significant(P＜0.05).After treatment,the total scores of ABC and CARS in "Jin San Needle"+ESDM group were lower than those in ESDM group and conventional rehabilitation group,and the differences were statistically significant (P＜0.05).The total scores of ABC and CARS in ESDM group were lower than those in conventional rehabilitation group,and the differences were statistically significant (P ＜0.05).There were no adverse reactions in the ESDM group and the conventional rehabilitation group,and only two cases of bleeding at the acupuncture site occurred in the"Jin San Needle"+ESDM group,there was no statistical significance in the incidence of adverse reactions among the three groups (P＞0.017).Conclusion "Jin San Needle"combined with ESDM in the treatment of GDD with ASD has a good overall effect,which can effectively promote the improvement of developmental delay and ASD behavioral symptoms in children,reduce the severity of the disease,and improve the overall development level,with high safety.