Osteoporosis as one of the most common metabolic bone diseases in clinical practice,which is an urgent problem to be solved in China and even the world.There is a lack of safe and effective methods for Western medicine treatment,and more and more scholars have turned their attention to the treatment of traditional Chinese medicine.Osteoporosis belongs to the category of＂bone flaccdity＂in Chinese medicine,in which the medical syndrome types are complex and diverse,and the traditional theory believes that＂kidney deficiency is the basis,and blood stasis is the standard＂is the pathogenesis,and the treatment is mainly to＂replenish the kidney and activate the blood＂.This article mainly discusses the pathogenesis mechanism of renal deficiency and blood stasis osteoporosis,and expands the new theoretical relationship named ＂brain-bone connection＂.In terms of treatment,broke through the traditional treatment theory,and proposes a new treatment strategy for the direct treatment of osteoporosis through the＂kidney-marrow-bone＂pathway on the one hand,and on the other hand the indirect treatment of osteoporosis through the ＂kidney-medulla-brain-bone＂ pathway through the regulation of the central nervous system.In order to demonstrate a new treatment path from the brain to the bone,give full play to the characteristics and advantages and improve the theoretical system of traditional Chinese medicine,provide clinical guidance for the prevention and treatment of osteoporosis,and provide ideas for further research.