磺达肝癸钠联合寿胎丸加减方治疗肾虚血瘀型抗心磷脂抗体阳性复发性流产的临床效果

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Abstract Objective To explore the effect of Fondaparinux Sodium combined with Modified Shoutai Formula in the treatment of recurrent spontaneous abortion(RSA)with positive anti cardiolipin antibody due to kidney deficiency and blood stasis.Methods A total of 105 RSA patients admitted to Jiangxi Maternal and Child Health Hospital from January to December 2021 were selected as research objects,and they were divided into simple Chinese medicine group,control group and observation group according to random number table method,with 35 cases in each group.The simple Chinese medicine group was treated with Modified Shoutai Formula,the control group was treated with Enoxaparin+Modified Shoutai Formula,and the observation group was treated with Fondaparinux Sodium+Modified Shoutai Formula.The efficacy,negative conversion rate of anti cardiolipin antibody,coagulation index and adverse reactions of the three groups were observed.Results The total effective rate of patients in the observation group and control group at 12 weeks of pregnancy was higher than that in the simple traditional Chinese medicine group,with statistical significant difference(P＜0.017).However,there was no statistical significant difference in the total effective rate between the observation group and the control group(P＞0.017).The conversion rate of anticardiolipin antibodies in the observation group and the control group was higher than that in the simple traditional Chinese medicine group,with statistical significant difference (P＜0.017).The conversion rate of anticardiolipin antibodies in the observation group was higher than that in the control group,with a statistical significant difference(P＜0.017).The difference in the conversion rate of anticardiolipin antibodies among the three groups was statistically significant (P＜0.05).At 12 weeks of pregnancy,the serum D-dimer levels,coagulation index,and maximum amplitude of the three groups of patients were lower than those before treatment,and the indexes of observation group and control group were lower than those of the simple traditional Chinese medicine group,with statistical significant differences(P＜0.05).However,there were no statistical significant differences in coagulation related indicators between the observation group and the control group(P＞0.05).During the treatment period,there were no adverse reactions in the group treated with traditional Chinese medicine alone.The incidence of skin reactions and elevated transaminases at the injection site in the control group were higher than those in the observation group,with a statistical significant difference(P＜0.05).Conclusion The effect of Fondaparinux Sodium combined with Modified Shoutai Formula in the treatment of RSA patients with positive anti cardiolipin antibody of kidney deficiency and blood stasis is significant,which can effectively improve the clinical symptoms and coagulation status,promote the negative conversion of anti cardiolipin antibody,and has better safety.

Key words： Recurrent spontaneous abortion Modified Shoutai Formula Fondaparinux Sodium Kidney deficiency and blood stasis Anti cardiolipin antibody

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[1]	Deng T，Liao X，Zhu S.Recent Advances in Treatment of Recurrent Spontaneous Abortion[J].Obstet Gynecol Surv，2022，77（6）：355-366.
[2]	崔佳，王霞，张明明，等.补肾健脾安胎汤联合西医治疗抗磷脂抗体阳性复发性流产效果观察[J].现代中西医结合杂志，2021，30（32）：3602-3604.
[3]	钟伟芬，晏红锦，杨丽君，等.低分子肝素治疗复发性流产患者凝血及血液流变学状态观察[J].中国计划生育和妇产科，2020，12（5）：29-32.
[4]	张利明，白艳梅.依诺肝素钠用于治疗D 二聚体异常升高复发性流产的效果[J].血栓与止血学，2022，28（1）：79-80，83.
[5]	张晓燕，王丽娟.丹红注射液联合磺达肝癸钠治疗肺栓塞的临床研究[J].现代药物与临床，2018，33（10）：2556-2561.
[6]	中华医学会妇产科学分会产科学组.复发性流产诊治的专家共识[J].中华妇产科杂志，51（1）：3-9.
[7]	罗颂平.中医妇科学[M].北京：高等教育出版社，2008：90.
[8]	郑筱萸.中药新药临床研究指导原则（试行）[M].北京：中国医药科技出版社，2002：253-258.
[9]	袁金兰，罗琼秀.抗凝治疗对复发性流产伴子宫动脉阻力指数增高患者血栓前状态和妊娠结局的影响[J].中国当代医药，2022，29（11）：67-70.
[10]	晋家萍，朱廷芬，马翠.复发性流产患者保胎中采用低分子肝素治疗的效果及安全性[J].妇儿健康导刊，2022，1（8）：111-114.
[11]	左瑾楠，于潇，张兵，等.刘金星预培其损治疗早期复发性流产用药规律分析[J].中国医药科学，2023，13（11）：82-86.
[12]	汤珏瑶，何翠琴，吴旭红，等.固肾通任化瘀方联合依诺肝素钠对肾虚血瘀型复发性流产患者血清I-309，MIP-1α 水平及妊娠结局的影响观察[J].四川中医，2021，39（11）：174-177.
[13]	杨梅萍，何可，李岚.寿胎丸对复发性流产患者临床症状、性激素水平、子宫内膜容受性和妊娠结局的影响[J].妇儿健康导刊，2022，1（10）：98-100.
[14]	冯晓玲，常卓，潘琳，等.TNF-α，NF-κB 在抗心磷脂抗体阳性复发性流产患者蜕膜和血清中表达及相关性分析[J].世界中西医结合杂志，2020，15（6）：991-994.
[15]	莫琳玲，彭丹，宋金玲，等.低分子肝素与小剂量阿司匹林治疗复发性流产血栓前状态的效果及其免疫调节作用研究[J].中国性科学，2022，31（9）：81-85.
[16]	张琛，刘国莉.低分子肝素在产科应用的研究进展[J].中国妇产科临床杂志，2022，23（4）：433-435.
[17]	李媛，李晓倩，冯乐.自拟安胎方联合低分子肝素干预复发性流产妇女血栓前状态的疗效观察[J].贵州医药，2023，47（1）：91-92.
[18]	Jacobson B，Rambiritch V，Paek D，et al.Safety and Efficacy of Enoxaparin in Pregnancy：A Systematic Review and Meta-Analysis[J].Adv Ther，2020，37（1）：27-40.
[19]	Khan MY，Ponde CK，Kumar V，et al.Fondaparinux：A cornerstone drug in acute coronary syndromes[J].World J Cardiol，2022，14（1）：40-53.
[20]	中华医学会临床药学分会《磺达肝癸钠药学实践专家共识》编写工作组童荣生.磺达肝癸钠药学实践专家共识[J].医药导报，2022，41（11）：1571-1581.
[21]	徐勇，柏光泽，李雷，等.磺达肝癸钠联合瘀血痹片预防全膝关节置换术后下肢深静脉血栓栓塞症的临床研究[J].中国医药科学，2022，12（7）：98-101，138.
[22]	李雪梅，聂晓红，向莉莉，等.磺达肝癸钠与依诺肝素钠预防肺血栓栓塞症对比研究[J].实用医学杂志，2022，38（17）：2216-2220.
[23]	孔苗，何绪成，舒亚民，等.基于FAERS 数据库的低分子肝素与磺达肝癸不良事件信号挖掘研究[J].中南药学，2022，20（9）：2161-2170.
[24]	谢星星，刘学，雷丹丹，等.选择性凝血因子Xa 抑制剂：磺达肝癸钠的临床应用研究进展[J].心血管病学进展，2022，43（7）：652-656.