脂肪干细胞治疗类风湿性关节炎的研究进展

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Abstract Rheumatoid arthritis is a chronic autoimmune disease that progresses to cause severe damage to the joints and surrounding tissues.At present,the main methods at home and abroad are to slow down the course of the disease by means of drug therapy after timely diagnosis,and help patients improve and maintain joint mobility and muscle strength.Although the current treatment methods of rheumatoid arthritis are relatively mature,more safe and effective therapies are still needed to achieve clinical remission and repair and regeneration of the disease.Studies at home and abroad have found that adipose-derived stem cells have good therapeutic effect in inflammatory arthritis,which has become a research hotspot in recent years.Adipose-derived stem cells are pluripotent stromal cells with low immunogenicity and strong ability of proliferation,differentiation and immune regulation,and can secrete a variety of cytokines to inhibit the occurrence and development of inflammation,providing a new idea for the treatment of rheumatoid arthritis.Based on a large number of Chinese and foreign literatures,this study summarized the progress of adipose-derived stem cells in the treatment of rheumatoid arthritis,in order to provide reference for its clinical research.

Key words： Adipose-derived stem cell Rheumatoid arthritis Extracellular vesicles Repair of cartilage injury

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2024/V31/I15/189

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