血清抗衰老因子、分泌型卷曲相关蛋白-1、C 反应蛋白在糖尿病肾病患者检测中的临床价值

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Abstract

Objective To investigate the clinical value of serum anti-aging factor (Klotho),secreted frizzled related protein-1 (sfrp-1)and C-reactive protein (CRP)in the detection of diabetic nephropathy (DN)patients.Methods By retrospective analysis,60 patients with DN admitted to the First People's Hospital of Jiujiang from November 2020 to November 2022 were selected as the DN group,and 60 healthy subjects who underwent physical examination during the same period were included as the control group.The changes of serum Klotho,sfrp-1 and CRP levels in the DN group and the control group were detected.The DN group was divided into simple diabetes group (urinary protein excretion rate [UAER]＜20 μg/min],early DN group (200 μg/min≥UAER≥20 μg/min) and clinical DN group (UAER＞200 μg/min),and the serum levels of Klotho,sfrp-1 and CRP were compared among all groups.The diagnostic value of serum Klotho,sfrp-1 and CRP on the degree of renal injury was analyzed by receiver operating characteristics (ROC) curve.Results The levels of sfrp-1 and CRP in DN group were higher than those in control group,and the level of Klotho wes lower than that in control group,with statistical significance (P＜0.05).The level of Klotho in clinical stage DN group was lower than that in early stage DN group and simple diabetes group,the level of Klotho in the early DN group was lower than that in the simple diabetes group,and the levels of sfrp-1 and CRP in clinical stage DN group were higher than those in early stage DN group and simple diabetes group,the levels of sfrp-1 and CRP in early stage DN group were higher than those in simple diabetes group,with statistical significance(P＜0.05).Spearman analysis showed that Klotho level was negatively correlated with the degree of kidney injury in DN patients,while Psfrp-1 and CRP levels were positively correlated with the degree of kidney injury (P＜0.05).The area under ROC curve (AUC)of Klotho,sfrp-1 and CRP combined in the diagnosis of kidney injury was higher than that of single detection.Conclusion The higher the degree of renal injury in DN patients,the higher the level of serum sfrp-1 and CRP,and the lower the level of serum Klotho.

Key words： Diabetic nephropathy Anti-aging factor Secreted frizzled related protein-1 C-reactive protein

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[1]	Thomas S，Karalliedde J.Diabetic nephropathy[J].Medicine，2019，47（2）：86-91.
[2]	Jiao Y，Jiang S，Wang Y，et al.Activation of complement C1q and C3 in glomeruli might accelerate the progression of diabetic nephropathy：Evidence from transcriptomic data and renal histopathology[J].J Diabetes Investig，2022，13（5）：839-849.
[3]	Wang Q，Ren D，Li Y，et al.Klotho attenuates diabetic nephropathy in db/db mice and ameliorates high glucoseinduced injury of human renal glomerular endothelial cells[J].Cell Cycle，2019，18（6-7）：696-707.
[4]	Sinha SK，Nicholas SB，Sung JH，et al.hs-CRP Is Associated With Incident Diabetic Nephropathy：Findings From the Jackson Heart Study[J].Diabetes Care，2019，42（11）：2083-2089.
[5]	覃晓虹，陆大卿.早期糖尿病肾病患者血清分泌型卷曲相关蛋白1 表达及临床意义[J].中国中西医结合肾病杂志，2019，20（5）：439-440.
[6]	中华医学会肾脏病学分会专家组.糖尿病肾脏疾病临床诊疗中国指南[J].中华肾脏病杂志，2021，37（3）：50.
[7]	李娜，杨爽，林卫红.糖尿病肾病患者同型半胱氨酸水平与颈动脉粥样硬化关系的研究[J].中风与神经疾病杂志，2022，39（8）：731-735.
[8]	Thipsawat S.Early detection of diabetic nephropathy in patient with type 2 diabetes mellitus：A review of the literature[J].Diab Vasc Dis Res，18（6）：14791641211058856.
[9]	Opazo-Ríos L，Mas S，Marín-Royo G，et al.Lipotoxicity and Diabetic Nephropathy：Novel Mechanistic Insights and Therapeutic Opportunities[J].Int J Mol Sci，2020，21（7）：2632.
[10]	刘凌云，郭进玲，葛渊.糖尿病肾病患者血清SFRP5、Klotho 表达量与氧化应激、脂肪细胞因子分泌的相关性[J].海南医学院学报，2017，23（22）：3070-3072，3076.
[11]	黄敏，陈颖，成水芹，等.骨化三醇联合坎地沙坦对早期糖尿病肾病的疗效及对血清Klotho 与Vaspin 水平的影响[J].中国现代医学杂志，2020，30（7）：53-58.
[12]	刘建梅，贾俊亚，闫铁昆，等.外源性Klotho 对糖尿病肾病小鼠成骨细胞甲状旁腺激素刺激的分化活性调控作用[J].山东医药，2021，61（33）：20-23.
[13]	Dong QL，Zhao XH，Wang Q，et al.Anti-aging gene Klotho ameliorates diabetic nephropathy in mice by inhibiting FGF2 signaling pathway[J].J Biol Regul Homeost Agents，2020，34（4）：1369-1377.
[14]	丁浩，危志强，蔡小琴，等.糖尿病肾病患者血清Klotho蛋白水平与血管病变的相关性[J].广东医学，2020，41（1）：66-71.
[15]	张方方，钱卫，高修银.Klotho、HE4、RBP4 联合检测在糖尿病肾病中的诊断价值[J].中国中西医结合肾病杂志，2022，23（12）：1110-1112.
[16]	Cui FQ，Gao YB，Wang YF，et al.Effect of Tang-Shen-Ning decoction on podocyte epithelial-esenchymal transformation via inhibiting Wnt/β-catenin pathway in diabetic mice[J].Ann Publliat Med，2021，10（12）：12921-12936.
[17]	孟庆敏，余莹，孔静，等.分泌型卷曲相关蛋白-1 在糖尿病肾病小鼠肾组织中的表达及意义[J].中国老年学杂志，2018，38（10）：2451-2454.
[18]	季伟琴.糖尿病肾病患者血清sfrp-1 水平及其与肾损害的关系研究[J].浙江医学，2020，42（6）：563-565，579.
[19]	曾夙莉，李华桦，梁峰翎，等.糖尿病肾病患者微炎症状态与营养状况及免疫功能的相关性分析[J].现代生物医学进展，2019，19（20）：3947-3950.
[20]	郝娟，段玉敏，郭晓宁.血清CRP，Hcy 与糖尿病肾病患者尿白蛋白/肌酐比值的相关性及临床意义[J].医学临床研究，2019，36（6）：1176-1178.