人类免疫缺陷病毒合并结核分枝杆菌感染患者的病原菌分布特征及药敏性

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Abstract Objective To explore the distribution characteristics and drug sensitivity of pathogenic bacteria in patients with human immunodeficiency virus(HIV)combined with Mycobacterium tuberculosis(MTB)infection.Methods A total of 142 HIV and MTB infected patients admitted to Jiujiang Third People's Hospital from January 2021 to May 2023 were selected as the study objects.They were divided into a simple HIV infection group(42 cases),a simple MTB infection group(42 cases),and a HIV combined with MTB infection group (58 cases) according to their infection status.The distribution of pathogenic bacteria and initial resistance to anti tuberculosis drugs in three groups of patients were recorded.Results Fungi were the most common in the HIV combined with MTB infection group,followed by Gram negative bacteria.Gram negative bacteria were the most common in the HIV infected group and MTB infected group.The proportion of fungal distribution in the HIV combined with MTB infection group was higher than that in the pure HIV infection group and the pure MTB group,and the difference was statistically significant(P＜0.017).There were no statistically significant differences among the three groups of Gram positive bacteria,Gram negative bacteria,and other pathogens (P＞0.05).The proportion of first-line anti tuberculosis drugs resistant to isoniazid(INH),streptomycin(SM),initial multidrug resistance,and total initial resistance in the HIV combined with MTB infection group were higher than those in the MTB alone group,and the differences were statistically significant(P＜0.05).There was no statistically significant difference between the two groups in terms of resistance to second-line anti tuberculosis drugs such as rifampicin (RFP),ethambutol (EMB),and resistance to second-line anti tuberculosis drugs (P＞0.05).Conclusion Patients with HIV combined with MTB infection carry more fungi than those with only two infections,and the patients with combined infections is high in INH,SM,and overall initial drug resistance.Clinical attention should be paid to this issue.

Key words： Human immunodeficiency virus Mycobacterium tuberculosis infection Distribution characteristics of pathogenic bacteria Drug sensitivity

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