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| Effect of Valsartan on the improvement of the condition and serum homocysteine and matrix metalloproteinase-9 levels in elderly patients with essential hypertension and mild cognitive impairment |
| LI Yuning1 LIU Yating1 YANG Dong2 ZHANG Wenhua3 ZENG Ni4 CAI Yamin1▲ |
1.Department of Pharmacy,the 921st Hospital of Joint Logistic Support Force of PLA,Hunan Province,Changsha 410000,China;
2.Clinical Laboratory,the 921st Hospital of Joint Logistic Support Force of PLA,Hunan Province,Changsha 410000,China;
3.Department of Pediatrics,the 3rd Hospital of Changsha,Hunan Province,Changsha 410000,China;
4.Department of Pharmacy,Hunan University of Chinese Medicine,Hunan Province,Changsha 410208,China |
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Abstract Objective To explore the effect of Valsartan on the condition improvement and serum homocysteine (Hcy)and matrix metalloproteinase-9(MMP-9)levels in elderly patients with essential hypertension and cognitive dysfunction.Methods A total of 142 elderly patients with essential hypertension combined with mild cognitive impairment admitted to the 921st Hospital of Joint Logistic Support Force of PLA from January 2019 to December 2022 were selected as the study objects,and were divided into observation group and control group by random number table method,with 71 cases in each group.The observation group was treated with Valsartan Capsules,and the control group was treated with Levamlodipine Besilate.The changes of heart rate,blood pressure,cognitive function,serum Hcy and MMP-9 levels before and after treatment were observed and compared between the two groups.Results There was no significant difference in heart rate between and within two groups before and after treatment (P＞0.05).There was no significant difference in the levels of systolic and diastolic blood pressure between the two groups before treatment (P＞0.05).The systolic blood pressure of the observation group was lower than that of the control group after treatment,and the difference was statistically significant (P＜0.05).However,there was no significant difference in diastolic blood pressure between the two groups after treatment (P＞0.05).There was no significant difference in the scores and total scores of cognitive function between the two groups before treatment (P＞0.05).After treatment,the four dimensions of delayed recall,abstraction,attention and language and the total score of cognitive function in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).There were no statistically significant differences in naming,orientation,visual spatial and executive function scores between the two groups after treatment(P＞0.05).There was no significant difference in serum Hcy and MMP-9 levels between the two groups before treatment (P＞0.05),but the serum Hcy and MMP-9 levels in the observation group were lower than those in the control group after treatment,and the differences were statistically significant(P＜0.05).Conclusion In elderly patients with essential hypertension with mild cognitive dysfunction,Valsartan and Levamlodipine Besilate can reduce blood pressure,improve cognitive dysfunction,and reduce serum Hcy and MMP-9 levels on average.In comparison,Valsartan has more obvious effects,which is worthy of clinical promotion and implementation.
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| [1] |
刘琳，李静，王春霞，等.原发性高血压合并腔隙性脑梗死患者发生认知功能障碍的影响因素[J].中国医师杂志，2022，24（6）：931-933.
|
| [2] |
Suleman R，Padwal R，Hamilton P，et al.Association between central blood pressure，arterial stiffness，and mild cognitive impairment[J].Clin Hypertens，2017，23：2.
|
| [3] |
丛慧文，徐雅琪，王爱民，等.XGBoost 算法在轻度认知障碍人群阿尔茨海默病发病预测中的应用[J].郑州大学学报（医学版），2022，57（6）：751-756.
|
| [4] |
李健，齐景林，潘为领，等.不同认知功能障碍程度阿尔茨海默病患者海马、内嗅皮层体积变化及其与MMSE 评分的关系[J].中华解剖与临床杂志，2023，28（3）：159-164.
|
| [5] |
朱斌斌，周彦伶，金陆飞，等.基于MRI 深度学习的阿尔茨海默病和轻度认知功能障碍智能诊断：方法与应用[J].中国神经精神疾病杂志，2022，48（4）：251-256.
|
| [6] |
邱微，俞勤凯.H 型高血压伴冠心病患者Hcy、MMP-9 和瘦素水平变化及相关性分析[J].河北医药，2023，45（2）：263-265，269.
|
| [7] |
《中国高血压防治指南》修订委员会.中国高血压防治指南2018 年修订版[J].心脑血管病防治，2019，19（1）：1-44.
|
| [8] |
中国防治认知功能障碍专家共识专家组.中国防治认知功能障碍专家共识[J].中华内科杂志，2006，45（2）：171-173.
|
| [9] |
Nasreddine ZS，Phillips NA，Bédirian V，et al.The Montreal Cognitive Assessment，MoCA：a brief screening tool for mild cognitive impairment[J].J Am Geriatr Soc，2005，53（4）：695-699.
|
| [10] |
白华，王磊，赵萱，等.冠心病患者认知功能障碍现状及发病风险预测[J].中国实用护理杂志，2022，38（4）：241-246.
|
| [11] |
Romero-Sevilla R，López-Espuela F，Fuentes JM，et al.Role of Inflammatory Cytokines in the Conversion of Mild Cognitive Impairment to Dementia：A Prospective Study[J].Curr Alzheimer Res，2022，19（1）：68-75.
|
| [12] |
王丽娟，冯淑君，聂坤.中国帕金森病轻度认知障碍的诊断和治疗指南（2020 版）[J].中国神经精神疾病杂志，2021，47（1）：1-12.
|
| [13] |
汪亚男，顾艳荭，谢传桃，等.老年轻度认知功能障碍早期识别最佳循证证据总结[J].解放军护理杂志，2021，38（8）：55-59.
|
| [14] |
黄小彦，孙林芳，张萍，等.老年人群发生轻度认知功能障碍的危险因素及其预防对策分析[J].长春中医药大学学报，2022，38（5）：565-568.
|
| [15] |
毛程璐，莫雨婷，杨丹，等.轻度认知功能障碍的中老年社区人群步态特征的探索[J].中风与神经疾病杂志，2023，40（1）：14-19.
|
| [16] |
Elias MF，Wolf PA，D'Agostino RB，et al.Untreated blood pressure level is inversely related to cognitive functioning：the Framingham Study[J].Am J Epidemiol，1993，138（6）：353-364.
|
| [17] |
张娜，杨敬源.高血压对社区老年人认知功能的影响[J].中华老年心脑血管病杂志，2008，10（10）：7-10.
|
| [18] |
Hajjar I，Hart M，Chen YL，et al.Effect of antihypertensive therapy on cognitive function in early executive cognitive impairment：a double-blind randomized clinical trial[J].Arch Intern Med，2012，172（5）：442-444.
|
| [19] |
孙霄龙，张蕾.厄贝沙坦联合阿托伐他汀治疗早期糖尿病肾病对患者内皮素水平的影响[J].山西医药杂志，2022，51（6）：661-664.
|
| [20] |
吴仕平，余凡.沙库巴曲缬沙坦治疗高血压合并心力衰竭对患者心功能及血浆脑钠肽水平的影响[J].中国医药科学，2022，12（13）：127-130.
|
| [21] |
文静，刘妍.沙库巴曲缬沙坦钠治疗维持性血液透析合并心力衰竭患者的效果[J].中国当代医药，2022，29（22）：10-13，17.
|
| [22] |
陈小翠，周望，王艺霖，等.H 型高血压患者血清基质金属蛋白酶-9、同型半胱氨酸与认知损害的关系[J].临床和实验医学杂志，2022，21（6）：582-585.
|
| [23] |
Huang L，Tian W，Chen X，et al.Peripheral Neutrophils-Derived Matrix Metallopeptidase-9 Induces Postoperative Cognitive Dysfunction in Aged Mice[J].Front Aging Neurosci，2022，14：683295.
|
| [24] |
杜彦梅，衣欣.沙库巴曲缬沙坦治疗射血分数保留心功能衰竭的效果分析[J].中国医药科学，2022，12（8）：142-146.
|
|
|
|
