淀粉样脑血管病相关心脏损伤的研究进展

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Abstract Cerebral amyloid angiopathy is a prevalent disease in the world,more common in elderly patients with Alzheimer's disease,and the end result is multiple microbleeding foci in the brain.It is characterized by the deposition of amyloid-β in the cerebral cortex and leptomeningeal blood vessel wall,which may induce the chronic inflammatory state of the brain and damage the integrity of the blood brain barrier by activating astrocytes,microglia,and pro-inflammatory substances.Cerebral amyloid angiopathy is the main cause of cognitive changes and intracerebral hemorrhage in the elderly,and patients are often associated with cardiac damage.Cardiac damage caused by cerebral amyloid angiopathy is a new area of research that requires in-depth analysis to provide therapeutic and preventive targets.

Key words： Amyloid cerebrovascular disease Amyloid-&beta Tau protein Transthyroxine amyloid Cardiac damage

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