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The pattern of medication use in the treatment of cough based on data mining of Peaceful Holy Benevolent Prescriptions |
ZHENG Runchen1 HU Shaozhen2 ZHANG Chuhan3 REN Xi4 |
1.School of Chinese Classics,Chengdu University of Traditional Chinese Medicine,Sichuan Province,Chengdu 611137,China; 2.Technology Innovation Center,Guangzhou University of Chinese Medicine,Guangdong Province,Guangzhou 510405,China;3.School of Humanities and Management,Guizhou University of Traditional Chinese Medicine,Guizhou Province,Gui'an 550025,China;4.Departmant of Respiratory and Chest Oncology,Hospital of Integrated Traditional Chinese Western and Southern Medicine University,Guangdong Province,Guangzhou 510515,China |
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Abstract Objective Explore the characteristics and patterns of medication treating cough in Volume 46 of Peaceful Holy Benevolent Prescriptions,and provide reference for clinical medication for treating cough.Methods All formulas in Volume 46 of Peaceful Holy Benevolent Prescriptions were entered into Excel,and the frequency of individual drugs in the formula was counted.Association rule analysis and system cluster analysis were used to analyze the drug association rules and core drug combinations.Results A total of 150 prescriptions were included,involving 176 drugs.The most frequently used drugs were almonds,liquorice,aster,ginger,mulberry white,Fritillaria cirrhosa,Schisandra chinensis, etc. The most common medicinal pairs were licorice and almonds,licorice and ginger,almonds and aster.The common drug combinations found based on association rules were licorice cinnamon,Schisandra chinensis(94.4% confidence),licorice tangerine peel(22.0% support).Through cluster analysis,two core main formulas were identified,namely Gancao Ganjiang Tang and Xingren Ziwan Wan.Conclusion Based on the frequency of medication and association rules,it can be concluded that Peaceful Holy Benevolent Prescriptions includes medication for treating cough,which mainly focuses on warming the lungs,lowering qi,resolving phlegm,and stopping cough.The medication tends to be sweet and warm.Based on the core prescription obtained from system clustering analysis,Gancao Ganjiang Tang is used as an addition or subtraction for cold cough,and Xingren Ziwan Wan is used as an addition or subtraction for hot cough,providing a reference for the treatment of cough medication ideas.
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