Objective To explore the effect of continuous nursing based on health belief in endocrine therapy of thyroid cancer patients after operation.Methods A total of 100 patients with thyroid cancer admitted to Pingxiang People's Hospital from January 2020 to May 2022 were selected as the study subjects.They were divided into the control group(50 cases)and the study group (50 cases) according to the method of random number table.The control group used conventional nursing methods,and the study group used continuous nursing methods based on health beliefs.The thyroid stimulating hormone(TSH)level,health belief questionnaire(HBQ)score,Morisk drug compliance questionnaire(MMAS-8)score and quality of life scale (EORTC QLQ-30)score of the two groups were compared.Results The compliance rate of TSH level in the study group was higher than that in the control group 1,3 and 6 months after intervention,and the differences were statistically significant (P＜0.05).HBQ scores at 1,3 and 6 months after intervention were lower in both groups than those before intervention,the differences were statistically significant (P＜0.05).The HBQ score of the study group was lower than that of the control group at 1,3 and 6 months after intervention,and the differences were statistically significant (P＜0.05).MMAS-8 scores in two groups at 1,3 and 6 months after intervention were higher than those before intervention,and the differences were statistically significant(P＜0.05).The MMAS-8 score of the study group was higher than that of the control group at 1,3 and 6 months after intervention,and the differences were statistically significant(P＜0.05).Before intervention,there were no significant differences in cognitive,emotional,role,social and physical scores between the two groups (P＞0.05).After intervention,the cognitive,emotional,role,social and physical scores of the two groups were higher than those before intervention,and the cognitive,emotional,role,social and physical scores of the study group were higher than those of the control group,the differences were statistically significant (P＜0.05).Conclusion The application of continuous nursing strategy based on health belief in the endocrine therapy of thyroid cancer patients after surgery can improve the rate of reaching the standard of TSH level,improve health belief and compliance with medication,and improve the quality of life.