标准外伤大骨瓣减压术联合高压氧治疗重型颅脑损伤患者的临床效果

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Abstract Objective To investigate the clinical effect of standard large traumatic bone flap decompression combined with hyperbaric oxygen in the treatment of severe craniocerebral injury. Methods The clinical data of 120 patients with severe craniocerebral injury admitted to the Department of Neurosurgery, Haicheng Hospital of Traditional Chinese Medicine, Liaoning Province from February 2018 to February 2019 were retrospectively analyzed. According to different treatment methods, they were divided into the control group and the observation group, with 60 cases in each group. Patients in control group were treated with standard large traumatic bone flap decompression, and patients in observation group were treated with standard large traumatic bone flap decompression plus hyperbaric oxygen therapy. Clinical efficacy, Glasgow coma scale (GCS), National Institutes of Health stroke scale (NIHSS) score and inflammatory factors(interleukin-6 [IL-6], interleukin-8 [IL-8], tumor necrosis factor-α [TNF-α]) were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05). After treatment, GCS of the two groups were higher than those before treatment,NIHSS scores were lower than those before treatment, and the differences were statistically significant (P＜0.05). After treatment, GCS of observation group was higher than that of the control group, NIHSS score was lower than that of the control group, and the differences were statistically significant (P＜0.05). After treatment, the levels of IL-6, IL-8 and TNF-α in the two groups were lower than those before treatment,and the differences were statistically significant(P＜0.05).After treatment,the levels of IL-6,IL-8 and TNF-α in observation group were lower than those in control group, and the differences were statistically significant (P＜0.05). Conclusion After standard decompression of large traumatic craniotomy combined with hyperbaric oxygen, the clinical treatment effect of severe craniocerebral injury patients is significant,the level of inflammation is significantly reduced, and the neurological function is recovered and the prognosis is good.

Key words： Severe craniocerebral injury')" href="#"> Severe craniocerebral injury Hyperbaric oxygen Standard trauma decompression of large bone flap;Nerve defect Prognosis Inflammatory response Clinical efficacy Combined therapy

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SUI Bin. Clinical effect of standard large traumatic flap decompression combined with hyperbaric oxygen in the treatment of severe craniocerebral injury[J]. 中国当代医药, 2022, 29(4): 111-114.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I4/111

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