十二指肠与空回肠间质瘤临床病理特征比较及预后影响因素

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Abstract

Objective To analyze the clinicopathological characteristics of duodenal stromal tumors(D-GIST)and jejunoileum stromal tumors(JI-GIST)and the risk factors for postoperative recurrence and prognosis.Methods The data of 92 patients with small intestinal stromal tumors admitted to Suzhou Dushu Lake Hospital from January 2008 to August 2017 were retrospectively analyzed,including 23 cases of D-GIST and 69 cases of JI-GIST.The clinicopathological features,recurrence and prognostic factors were analyzed.Results In terms of clinicopathological characteristics,the first symptoms of the two groups were different.The most common first symptom of D-GIST was gastrointestinal bleeding(52.2%),while the most common first symptom of JI-GIST was abdominal pain(39.1%),and the difference was statistically significant(P<0.05).The proportion of JI-GIST tumor diameter>5 cm and the proportion of high-risk patients were higher than those of D-GIST,and the differences were statistically significant(P<0.05).The total recurrence rate of JI-GIST was higher than that of D-GIST group,and the difference was statistically significant(P<0.05).There was no significant difference in overall survival rate between the two groups(P>0.05).Multivariate Cox analysis showed that tumor diameter>5 cm and mitotic figure>5/50 HPF were independent risk factors for recurrence of small intestinal stromal tumor.Age>60 years,tumor diameter>5 cm,mitotic figure>5/50 HPF were independent risk factors for survival and prognosis of patients with small intestinal stromal tumors.Conclusion Compared with JI-GIST,D-GIST is easier to be diagnosed early and has a lower risk of postoperative recurrence.To reduce recurrence and improve prognosis,we should pay more attention to tumor diameter>5 cm,mitotic figure>5/50 HPF and elderly patients.

Key words： Duodenal stromal tumor Jejunoileum stromal tumors Clinicopathological features Recurrence Prognosis

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	SHAN Zhili

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SHAN Zhili. Comparison of clinicopathological features and prognostic factors of duodenal and jejunoileum gastrointestinal stromal tumors[J]. 中国当代医药, 2022, 29(29): 20-23.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I29/20

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