右旋糖酐铁联合促红细胞生成素对妊娠期缺铁性贫血患者网织红细胞、铁调素-25水平的影响

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Abstract Objective To explore the application effect of Iron Dextran combined with erythropoietin (EPO) on the levels of reticulocyte (RET) and hepcidin-25 in patients with iron deficiency anemia during pregnancy. Methods A total of 80 pregnant women with iron deficiency anemia during pregnancy who were treated in Shangrao People′s Hospital between July and December 2021 were selected as the research subjects, and they were divided into observation group(40 cases) and control group (40 cases) by random number table method. The patients in the control group were treated with EPO, while the patients in the observation group were additionally given Iron Dextran on the basis of the control group. The anemia-related indicators, including hemoglobin (Hb), mean corpuscular volume (MCV) and EPO levels were observed and compared between the two groups. Serum iron related indexes, including ferritin (SF) level, hepcidin-25, membrane transporter 1 (FPN1), hemojuvelin (HJV) level and soluble transferrin receptor (sTfR) level were compared between the two groups. Hematological indexes, including RET count, mature RET ratio (MFR), immature RET fraction (IRF), low fluorescence RET ratio (LFR) and hemoglobin content (RET-He) were compared between the two groups. Results Before treatment, there were no significant differences in the levels of Hb, MCV, EPO, SF, sTfR,hepcidin-25, FPN1, HJV, RET, MFR, IRF, LFR and RET-He between the two groups (P>0.05). After 1 month of treatment, the levels of Hb and MCV in the observation group were higher than those in the control group, and the level of EPO in the observation group was lower than that in the control group, and the differences were statistically significant(P<0.05). After 1 month of treatment, the levels of SF, hepcidin-25 and HJV in the observation group were higher than those in the control group, and the levels of sTfR and FPN1 in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). After 1 month of treatment, the levels of RET,MFR and IRF in the observation group were lower than those in the control group, and the levels of LFR and RET-He in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05). Conclusion The application of Iron Dextran combined with EPO in the treatment of patients with iron deficiency anemia during pregnancy can inhibit the abnormal expression of RET and hepcidin-25 levels, which can effectively improve the anemia status of patients.

Key words： Iron Dextran Erythropoietin Pregnancy Iron deficiency anemia Reticulocyte Hepcidin-25

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	ZHONG Li
	ZHANG Ge

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ZHONG Li,ZHANG Ge. Effect of Iron Dextran combined with erythropoietin on the levels of reticulocyte and hepcidin-25 in patients with iron deficiency anemia during pregnancy[J]. 中国当代医药, 2022, 29(27): 104-107.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I27/104

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