中国当代医药
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中国当代医药  2022, Vol. 29 Issue (21): 75-77转81    DOI:
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Effect of endocrine changes on bone metabolism and bone mineral density in patients with polycystic ovary syndrome
HAN Zhe1   CUI Zhaohui1   LI Xinning1   LI Jiena2   ZHENG Zhixin3▲
1. Department of Orthopaedic Surgery, Heze Municipal Hospital, Shandong Province, Heze   274000, China; 
2. Department of Obstetrics and Gynecology, Heze Municipal Hospital, Shandong Province, Heze   274000, China; 
3. Department of Spine Surgery, Heze Municipal Hospital, Shandong Province, Heze   274000, China
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Abstract  Objective To investigate the effect of endocrine hormonal changes on bone metabolism and bone mineral density in polycystic ovary syndrome (PCOS). Methods A total of 129 patients admitted to the Department of Gynecology and Obstetrics of Heze Municipal Hospital from January 2020 to September 2021 were selected as the research objects, 71 patients with PCOS were included in the PCOS group, and the remaining 58 premenopausal patients were included in the non PCOS group. The levels of serum 25-hydroxy vitamin D (25-[OH]VD), osteocalcin (OC), total N-terminal propeptide of typeⅠprocollagen (TP1NP), β-C-terminal telopeptide of type-Ⅰcollagen (β-CTX), total parathyroid hormone (PTH) and bone mineral density, related sex hormone were compared between two groups. Results The levels of luteinizing hormone/follicle stimulating hormone (LH/FSH), total testosterone (TT) and homeostasis model assessment-insulin resistance (HOMA-IR) in the PCOS group were higher than those of the non-PCOS group, the differences were statistically significant (P<0.05). The levels of 25-(OH)VD, OC, β-CTX, TP1NP, total T value in the PCOS group were lower than those of the non-PCOS group, the differences were statistically significant (P<0.05). There were no significant differences in the levels of estradiol, PTH and plasma fasting insulin (FINS) between the two groups (P>0.05). Conclusion Endocrine changes in PCOS patients cause bone metabolism changes and bone mineral density decline, which provide important clinical data for preventing and delaying the occurrence of osteoporosis.
Key wordsPolycystic ovary syndrome      Bone metabolism      Bone mineral density      Osteoporosis     
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HAN Zhe
CUI Zhaohui
LI Xinning
LI Jiena
ZHENG Zhixin
Cite this article:   
HAN Zhe,CUI Zhaohui,LI Xinning, et al. Effect of endocrine changes on bone metabolism and bone mineral density in patients with polycystic ovary syndrome[J]. 中国当代医药, 2022, 29(21): 75-77转81.
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