扩血管药物联合镇静药在伴抑郁的冠心病患者中的应用效果

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Abstract Objective To study the clinical effect of vasodilators combined with sedatives in the treatment of patients with coronary heart disease (CHD) with depression patients. Methods A total of 50 CHD patients with depression treated from June 2020 to September 2021 in Guangzhou Hospital of Integrated Traditional Chinese and Western Medicine were selected for the study. The patients were divided into group A and group B according to random number table method, with 25 cases in each group. Group B was treated with vasodilators alone, and group A was treated with vasodilators combined with sedatives. The clinical effect of the two groups after intervention were compared. The degree of depression of the two groups was evaluated by self-rating depression scale (SDS), and the quality of life of the two groups was evaluated by Seattle angina pectoris quality of life scale (SAQ). At the same time, the changes in indicators of the left ventricular ejection fraction (LVEF), left ventricular end systolic volume index (LVESVI), high-sensitivity Creactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α) were measured. Results There were no significant differences in the indicators of LVEF, LVESVI, hs-CRP and TNF-α between the two groups before treatment (P＞0.05).After treatment, the indicators of LVEF of the two groups were higher than those before treatment, the indicators of LVESVI, hs-CRP and TNF-α of the two groups were lower than those before treatment, the indicators of LVEF in group A after treatment was higher than that in group B, the indicators of LVESVI, hs-CRP and TNF-α in group A after treatment were lower than those in group B, and the differences were statistically significant (P＜0.05). There were no significant differences in the scores of SDS and SAQ between the two groups before treatment (P＞0.05). The SDS scores of the two groups after treatment were lower than those before treatment, and the SAQ scores of the two groups after treatment were higher than those before treatment, the SDS score of group A after treatment was lower than that of group B, and the SAQ score of group A after treatment was higher than that of group B, the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion For CHD patients with depression, the treatment of vasodilators combined with sedatives has a good clinical effect, which can promote the recovery of prognosis, improve the indexes of cardiac function, reduce the indexes of inflammatory factors, reduce the degree of depression, improve the prognosis and improve the quality of life of patients, which is worthy of reference.

Key words： Vasodilators Sedatives Coronary heart disease Depression Nicorandil Alprazolam

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	LI Xingzhou
	XU Yulian

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LI Xingzhou,XU Yulian. Application effect of vasodilators combined with sedatives in patients with coronary heart disease with depression[J]. 中国当代医药, 2022, 29(16): 91-94转99.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I16/91

[1]	陈秋玲，周桂保，李宽，等.苦碟子注射液联合尼可地尔治疗冠心病心绞痛的临床观察[J].广西医学，2021，43（13）：1583-1586.
[2]	王海洋.尼可地尔联合曲美他嗪对冠心病病人PCI 术后心功能及ADL 评分的影响[J].中西医结合心脑血管病杂志，2021，19（12）：2061-2063.
[3]	李靓，翟清，杨洋，等.尼可地尔联合替格瑞洛对冠心病患者PCI 术后心功能及血清cTnI、NT-proBNP 水平的影响[J].医学综述，2021，27（15）：3084-3089.
[4]	刘雯，伍芳.尼可地尔对冠心病介入治疗后心绞痛患者血清CAT、SOD 水平的影响[J].贵州医药，2021，45（2）：194-195.
[5]	贾玲，徐予.冠心病的诊断与治疗[M].北京：军事医学科学出版社，2002：4，130.
[6]	郝伟，陆林.精神病学[M].8 版.北京：人民卫生出版社，2018：91-96.
[7]	孙毅，张权宇，刘威，等.经皮冠状动脉介入治疗术后冠心病患者合并焦虑和（或）抑郁对预后影响[J].临床军医杂志，2020，48（5）：518-520，525.
[8]	侯季秋，安莹，陈雅丽，等.中药治疗对冠心病合并焦虑抑郁患者炎性因子影响的系统评价及Meta 分析[J].中国实验方剂学杂志，2021，27（13）：153-163.
[9]	王晓芳，蒙婷，马伶.丹参多酚注射液联合尼可地尔治疗冠心病不稳定型心绞痛（痰瘀互结型）临床疗效及对血清学指标的影响[J].湖北中医药大学学报，2021，23（1）：18-21.
[10]	沈志强，郭道骝，奚广军.枣仁安神胶囊联合阿普唑仑对老年性失眠伴焦虑抑郁的效果及血液流变学的影响[J].西北药学杂志，2020，35（2）：283-287.
[11]	尚良，董平栓，杨旭明，等.阿普唑仑联合氟哌噻吨美利曲辛治疗急性ST 段抬高型心肌梗死PCI 术后合并焦虑抑郁患者的疗效及对生活质量的影响[J].解放军预防医学杂志，2019，37（3）：28-29，32.
[12]	李巧云，杨芳，黄明燕，等.阿普唑仑联合放松训练治疗广泛性焦虑障碍患者的临床疗效观察[J].癫痫与神经电生理学杂志，2020，29（5）：295-299.
[13]	李小琴.扩血管药物联合抗抑郁药物对伴抑郁的冠心病患者的疗效[J].国际精神病学杂志，2021，48（3）：482-484.
[14]	唐慧明，陈孝强，许月红，等.生物反馈对稳定型心绞痛冠心病患者焦虑和抑郁状态的影响[J].海军医学杂志，2020，41（6）：692-694.
[15]	狄美琪，胡玲玲，桂树华，等.盐酸氟西汀分散片联合阿普唑仑片治疗脑梗死恢复期患者的临床研究[J].中国临床药理学杂志，2021，37（13）：1631-1633，1637.
[16]	余航，马云燕.不同刺激强度针刺疗法联合阿普唑仑对原发性失眠肝郁化火证患者血浆NPY、5-HT 水平的影响[J].四川中医，2021，39（7）：186-189.
[17]	徐亮，郑艳，江磊磊，等.重复经颅磁刺激联合阿普唑仑治疗失眠症伴焦虑患者的效果分析[J].现代生物医学进展，2021，21（8）：1533-1536，1483.
[18]	张巍献，路淑淑，何云鹏，等.唑吡坦与阿普唑仑治疗失眠症有效性与安全性的Meta 分析[J].精神医学杂志，2020，33（5）：363-366.
[19]	曹江，张岩，沈文婧.自拟涤痰汤辅助阿普唑仑治疗中青年急性脑梗死伴OSAHS 疗效及对炎性细胞因子、氧化应激指标的影响[J].中国中医急症，2019，28（2）：343-345.
[20]	毕磊，田国祥，樊茹，等.尼可地尔对高龄老年冠心病合并2 型糖尿病患者血运重建后心绞痛及血管内皮功能的影响[J].中国循证心血管医学杂志，2021，13（10）：1179-1181.