康达心口服液对心肾综合征大鼠氧化应激的影响

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Abstract Objective To investigate the effect and potential mechanism of Kangdaxin Oral Liquid on cardiorenal syndrome (CRS) rats.Methods Sixty SD rats were randomly divided into 5 groups:sham operation (sham) group,heart failure (HF) group,CRS group,HF+intervention (I) group and CRS+I group.Left ventricular ejection fraction (LVEF)and left ventricular shortening fraction (FS) were measured by cardiac color ultrasound.The levels of serum N-terminal pro-B type natriuretic peptide (NT-proBNP),creatinine (Cr),urea nitrogen (Bun),total antioxidant capacity (TAOC),superoxide dismutase (SOD),malondialdehyde (MDA) were determined by ELISA.Results The FS and LVEF values of rats in HF group,HF+I group,CRS group and CRS+I group were lower than those in sham group,and serum NT-proBNP level was higher than that in sham group,the differences were statistically significant (P<0.05).The FS and LVEF values in HF+I group were higher than those in HF group,and the level of NT-proBNP was lower than that in HF group,the differences were statistically significant (P<0.05).The FS and LVEF values of CRS+I group were higher than those of CRS group,and the level of NT-proBNP was lower than that of CRS group,the differences were statistically significant (P<0.05).The levels of serum Cr and Bun in CRS group and CRS+I group were higher than those in sham group,and the differences were statistically significant (P<0.05).The levels of serum Cr and Bun in CRS+I group were lower than those in CRS group,the differences were statistically significant (P<0.05).Serum TAOC and SOD levels in HF group,HF+I group,CRS group and CRS+I group were lower than those in sham group,while MDA level was higher than that in sham group,the differences were statistically significant (P<0.05).Serum T-AOC and SOD levels in HF+I group were higher than those in HF group,while MDA levels were lower than those in HF group,the differences were statistically significant (P<0.05).Serum T-AOC and SOD levels in CRS+I group were higher than those in CRS group,while MDA levels were lower than those in CRS group,the differences were statistically significant (P<0.05).Conclusion Kangdaxin Oral Liquid may improve cardiac function in rats with cardiorenal syndrome by promoting antioxidant capacity and suppressing oxidative stress.

Key words： Kangdaxin Oral Liquid Cardionrenal syndrome Oxidative stress Total antioxidant capacity Superoxide dismutase

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	WU Xiang
	ZHANG Tingting
	XIONG Shangquan

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WU Xiang,ZHANG Tingting,XIONG Shangquan. Effect of Kangdaxin Oral Liquid on oxidative stress in rats with cardiorenal syndrome[J]. 中国当代医药, 2022, 29(14): 10-13.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I14/10

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