|
|
Effect of local injection of Triamcinolone Acetonide combined with Levothyroxine Sodium in the treatment of Hashimoto's thyroiditis |
SUN Chuang |
Department of Endocrinology,Xincheng Hospital of Liaoyang Central Hospital,Liaoning Province,LiaoYang 111000,China |
|
|
Abstract Objective To explore and analyze the curative effect of local injection of Triamcinolone Acetonide combined with Levothyroxine Sodium in the treatment of Hashimoto's thyroiditis and its effect on serum visfatin and cytokines.Methods A total of 120 patients with Hashimoto's thyroiditis were treated in the Xincheng Hospital of Liaoyang Central Hospital selected from May 2018 to May 2020,the patients were divided into the control group and the observation group by random number table method,with 60 cases in each group.Control group was treated with Levothyroxine Sodium,and observation group was treated with local Triamcinolone Acetonide injection on the basis of control group.The efficacy,thyroid indexes,serum lipins and cytokines expression levels and the incidence of adverse reactions were compared between the two groups after 12 weeks of continuous treatment.Results The total clinical effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of thyroid stimulating hormone(TSH),thyroglobulin antibody(TGAb),thyroid microsomal antibody(TMAb),serum lipin,recombinant differentiated protein cluster 195(CD195)and recombinant differentiated protein cluster 30(CD30)in observation group were lower than those in control group,serum free triiodothyronine(FT3)and serum free thyroxine(FT4)were higher than those in control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The addition of local injection of Triamcinolone Acetonide to the treatment of Hashimoto's thyroiditis by Levothyroxine Sodium can better relieve clinical symptoms and signs,regulate thyroid-related indicators,improve serum visfatin and cytokine expression levels,and no obvious adverse reactions were seen during the treatment,and the safety is guaranteed.
|
|
|
|
|
[1] |
Cui Z,Wang Z,Liu X,et al.Establishment of clinical diagnosis model of Graves'disease and Hashimoto's thyroiditis[J].J Transl Med,2019,17(1):11-12.
|
[2] |
吴英萍,吴小翠,张永杰.加味门冬清肺饮联合左甲状腺素钠片治疗桥本甲状腺炎气阴两虚证临床研究[J].中国中医药信息杂志,2019,26(11):27-30.
|
[3] |
徐雯,李文波,朱庆莉,等.美国甲状腺协会指南甲状腺结节超声分类系统的临床应用价值[J].中华医学超声杂志(电子版),2017,14(7):526-531.
|
[4] |
张杰群,徐肖,刘雷.左甲状腺素钠联合复方丹参滴丸治疗桥本甲状腺炎的临床疗效及对自身免疫抗体的影响[J].广西医科大学学报,2018,35(2):220-221.
|
[5] |
中国医师协会检验医师分会.甲状腺疾病检验诊断报告模式专家共识[J].中华医学杂志,2017,97(18):1380-1386.
|
[6] |
苏亚,张哲,梁园芳,等.局部注射曲安奈德联合左甲状腺素钠对桥本氏甲状腺炎的疗效[J].西北药学杂志,2020,35(5):735-776.
|
[7] |
Lee EJ,Lee HS,Park JE,et al.Association Kikuchi disease with Hashimoto thyroiditis:a case report and literature review[J].Ann Pediatr Endocrinol Metab,2018,23(2):99-102.
|
[8] |
周玥,孙海峰,陈茹,等.硒酵母联合左甲状腺素钠对桥本甲状腺炎伴甲减患者血硒、甲状腺自身抗体的影响[J].心血管外科杂志(电子版),2020,9(2):69-70.
|
[9] |
任意,赵铁铮,王玉文,等.小金胶囊联合左甲状腺素钠片治疗桥本氏甲状腺炎的临床研究[J].中国中西医结合外科杂志,2020,26(3):465-470.
|
[10] |
王霏鹭,于圣.硒酵母联合左甲状腺素钠对桥本甲状腺炎伴甲减患者血硒、甲状腺自身抗体的影响[J].中国实用医药,2019,14(25):103-105.
|
[11] |
Lin ZM,Wang Y,Liu CM,et al.Role of Virtual Touch Tissue Quantification in Hashimoto's Thyroiditis[J].Ultrasound Med Biol,2018,44(6):1164-1169.
|
[12] |
任珍,张薇,王晓光.左甲状腺素钠联合硒酵母对桥本甲状腺炎甲状腺功能减退的疗效分析[J].中国慢性病预防与控制,2017,25(1):60-62.
|
[13] |
Cai YJ,Wang F,Chen ZX,et al.Hashimoto's thyroiditis induces neuroinflammation and emotional alterations in euthyroid mice[J].J Neuroinflamm,2018,15(1):299-300.
|
[14] |
贾瑞红.骨化三醇联合左甲状腺素钠片治疗桥本甲状腺炎伴甲状腺功能减退症疗效观察[J].医药论坛杂志,2020,41(2):133-135.
|
[15] |
丘博文,张荣木,林彪雄.曲安奈德联合锝云克治疗甲状腺相关眼病成效分析[J].中外医疗,2020,39(10):108-110.
|
[16] |
罗丽华,高立新,王薇,等.曲安奈德球侧及上穹隆部注射治疗中重度活动期甲状腺相关眼病的效果[J].眼科,2020,29(4):260-265.
|
[17] |
吕冬梅,尚敏捷,田晓颖,等.左甲状腺素钠片治疗妊娠期合并甲状腺功能减退的临床效果及对患者甲状腺激素水平变化的观察[J].中国当代医药,2021,28(21):125-127.
|
[18] |
郄华.硒酵母联合左旋甲状腺素治疗淋巴细胞性甲状腺炎的效果研究[J].中国医药科学,2020,10(8):53-55,236.
|
|
|
|