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| Application effect of Acetylcysteine for inhalation combined with Budesonide for inhalation in lung cancer patients with lower pulmonary function before and after surgery |
| OUYANG Zhi-cheng LIU Ping-xiang DONG Li-min |
| Department of Respiratory Medicine,Pingxiang People′s Hospital,Jiangxi Province,Pingxiang 337000,China |
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Abstract Objective To investigate the application effect of Acetylcysteine for inhalation combined with Budesonide for inhalation in lung cancer patients with lower pulmonary function before and after surgery.Methods A total of 40 lung cancer patients with lower pulmonary function who admitted in Pingxiang People′s Hospital from January 2018 to December 2019 were selected and divided into two groups according to random number table,20 cases in each group.The control group was given Budesonide for inhalation,and experimental group added Acetylcysteine.The pulmonary function (forced expiratory volume in first second [FEV1],forced expiratory volume in first second/forced vital capacity[FEV1/FVC],minute ventilation volume [MVV]),indexes of blood gas analysis (arterial partial pressure of oxygen [PaO2],arterial partial pressure of carbon dioxide [PaCO2]),hospital stays,use intensity and usage days of antibiotics,and complications were compared between two groups.Results The levels of FEV1 and FEV1/FVC in experimental group were higher than those in control group after discharge for 1 month(P<0.05).The level of PaO2 in experimental group was higher than that in control group after discharge for 1 month,the level of PaCO2 in experimental group was lower than that in control group,the hospital stays and usage days of antibiotics in experimental group were shorter than those in control group,and the use intensity of antibiotics in experimental group was lower than that in control group,the differences were statistically significant (P<0.05).There was no statistical difference in the incidence of complications between two groups (P＞0.05).Conclusion Acetylcysteine inhalation combined with Budesonide inhalation in lung cancer patients with lower pulmonary function before and after surgery can improve pulmonary function and indexes of blood gas analysis,shorten hospital stays,and reduce the use of antibiotics,which has high safety and is worthy of clinical promotion.
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| [1] |
薛锋，张璞，田燕妮.肺癌患者围手术期心肺功能变化及与病情发展的相关性研究[J].实用癌症杂志，2019，34（3）：514-516.
|
| [2] |
王丹，庞敏.慢性阻塞性肺疾病合并肺癌的临床特征分析[J].临床肺科杂志，2019，24（6）：1082-1085.
|
| [3] |
许冰.肺癌患者术前低肺功能对左全肺切除术后PCC 的预测能力分析[J].临床肺科杂志，2019，24（3）：507-510.
|
| [4] |
付伟，辛丽云，陈乾华.乙酰半胱氨酸溶液雾化吸入对COPD患者免疫功能及肺功能的影响[J].实用药物与临床，2019，22（6）：597-600.
|
| [5] |
孔育姗，谷刚，田科，等.布地奈德对嗜酸粒细胞性支气管炎患者的临床研究[J].中国临床药理学杂志，2019，35（22）：2797-2800.
|
| [6] |
杨汀.慢性阻塞性肺疾病吸入性三联药物治疗的研究进展[J].中华结核和呼吸杂志，2019，42（8）：637-639.
|
| [7] |
高占成.从肺功能改善看慢性阻塞性肺疾病的治疗进展[J].中华结核和呼吸杂志，2019，42（4）：314-317.
|
| [8] |
邢晓坤.布地奈德与异丙托溴铵治疗慢阻肺的效果和患者不良分析[J].医学食疗与健康，2019，21（18）：54，56.
|
| [9] |
李刚，王健生，秦思达，等.布地奈德联合氨溴索氧化驱动雾化吸入预防成人开胸术后肺炎的临床疗效[J].北京大学学报（医学版），2018，50（5）：840-844.
|
| [10] |
汤磊，赵艳.氧气驱动雾化吸入布地奈德与乙酰半胱氨酸联合治疗小儿毛细支气管炎的疗效观察[J].中国医院用药评价与分析，2019，19（5）：579-581.
|
| [11] |
俞峥，王新连，徐伟峰，等.布地奈德、异丙托溴铵、氨溴索联合雾化吸入对高龄肺癌患者围术期肺功能的保护[J].贵州医药，2018，42（8）：966-968.
|
| [12] |
盛伟利，赵莹，尹凤先，等.乙酰半胱氨酸雾化治疗囊状支气管扩张症的临床研究[J].中国医刊，2019，54（11）：1190-1192.
|
| [13] |
刘坚.丹红加乙酰半胱氨酸治疗特发性间质性肺炎的疗效评价[J].药品评价，2016，13（24）：40-42.
|
| [14] |
陈世谋，郭永明.乙酰半胱氨酸联合泼尼松治疗特发性肺间质纤维化的临床效果[J].中国当代医药，2019，29（6）：85-87.
|
| [15] |
李俊敏，朱建勇，邝军，等.布地奈德福莫特罗联合乙酰半胱氨酸对稳定期中重度慢性阻塞性肺疾病患者氧化应激的影响[J].临床内科杂志，2016，33（9）：620-622.
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