Objective To explore the application value of thrombelastography (TEG) in detection of blood coagulation function in women with gestational diabetes mellitus (GDM).Methods Clinical data of 142 GDM pregnant women who delivered in Chaohu Hospital of Anhui Medical University from October 2017 to October 2019 was were retrospectively analyzed and divided into the GDM group (70 cases) and the control group (72 cases) according to whether the pregnant women had GDM.The routine coagulation function,level of platelet (PLT) and TEG indicators were compared between the two groups.And the correlation analysis was conducted in routine coagulation function indicators and TEG indicators with statistical differences in the GDM group.Results The prothrombin time (PT) in the peripheral blood of the GDM group was longer than that of the control group,the fibrinogen (FIB) was higher than that of the control group,and the differences were statistically significance (P<0.01).The FIB values of the two groups were both higher than the normal range.There were no statistically significant differences in the activated partial thromboplastin time (APTT),thrombin time (TT),D-dimer (DD) and level of PLT between the two groups (P>0.05).The peripheral blood coagulation comprehensive index (CI),maximum amplitude (MA),blood clot mechanical strength (G) and amplitude (A) in the GDM group were higher than those in the control group,and the differences were statistically significant (P<0.05).There were no statistically significant differences in the reaction time (R),coagulation time (K),and clot formation rate (α angle)between the two groups (P>0.05).CI,G and A were positively correlated with PT in GDM group (P<0.05),CI,MA,G and A were positively correlated with FIB in GDM group (P<0.05).Conclusion The blood of women with GDM is prone to form thrombosis,and the thrombus is not easy to fall off.The risk of bleeding in GDM women is also higher than that of normal pregnant women.The TEG indicators are significantly correlated with traditional coagulation indicators.TEG testing for GDM patients is superior to traditional coagulation function detection,which can accurately monitor the patients′ blood status,and provide a basis for clinical anticoagulation and hemostasis.