某三甲医院感染性心内膜炎病原菌及耐药性分析

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Abstract Objective To explore the pathogenic bacteria and drug resistance of infective endocarditis, and to provide references for clinicians to apply antibiotics rationally. Methods A total of 107 inpatients with infective endocarditis(infective endocarditis) in a third-class hospital from June 1, 2014 to May 31, 2019 were selected for retrospective analysis, and 79 cases were selected for blood bacterial culture and drug sensitivity test. The pathogenic bacteria composition and drug resistance distribution in clinical data were analyzed. Results In 107 patients with infective endocarditis, 79 strains of non-duplicative pathogens were detected, including 75 strains of gram-positive bacteria(94.94%), including 31 strains of streptococcus (accounting for 39.24%), 22 strains of Staphylococcus aureus (accounting for 27.85%), and 4 strains of gram-negative bacteria (accounting for 5.06%), no cases of fungal infection were detected. Streptococcus was still the most common pathogenic bacteria (39.24%). Drug resistance analysis was showed that the drug resistance rate of Streptococcus bacteria to Penicillin was 90.32%. Of the 22 strains of Staphylococcus bacteria, 20 strains were resistant to Penicillin, and the drug resistance rate of Benzoxicillin was 81.82%. However, it was sensitive to antibiotics of special use grade, such as Vancomycin, Imipenem and Linezolid, and had no resistance.Conclusion The pathogenic bacteria of infective endocarditis are mainly gram-positive bacteria, and Streptococcus is still the most common. Gram-positive cocci are generally resistant to Penicillin. In order to ensure the efficacy and safety of antiinfective treatment, antibacterials should be selected empirically in combination with the local etiological data, and the drug regimen should be adjusted in time according to the results of drug susceptibility test.

Key words： Infective endocarditis Pathogenic bacteria Drug resistance Antibiotic

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	WANG Bo
	DING Guo-feng

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WANG Bo,DING Guo-feng. Analysis on pathogenic bacteria and drug resistance of infective endocarditis in a third grade hospital[J]. 中国当代医药, 2020, 27(26): 68-70.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2020/V27/I26/68

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