Abstract：Objective To investigate the application effect of Dexmedetomidine on postoperative laparoscopic gastric cancer in elderly patients.Methods From January 2016 to December 2017,a total of 80 elderly patients who underwent laparoscopic radical gastrectomy for gastric cancer were selected as objects and divided into the Dexmedetomidine group (group D)and the control group (group C)according to the random envelope method,with 40 cases in each group.Group D received Dexmedetomidine 1 μg/kg within 15 min,and then received that 0.4 μg/kg,while group C received the same volume of physiological saline.All patients were anesthetized with epidural anesthesia combined with intravenous anesthesia and received postoperative multimodal analgesia.The operation time,intraoperative fluid volume,anesthetic dose,length of hospital stay,postoperative nausea and vomiting,postoperative inflammatory response(C-reactive protein[CRP],interleukin-6[IL-6],erythrocyte sedimentation rate[ESR],neutrophil percentage[N]),and postoperative functional recovery(PQRS)(emotive domain[ED],nociceptive domain[ND],cognitive domain[CD],overall postoperative function recovery[OPR])were compared between the two groups.Results There were no significant differences in the operation time and intraoperative fluid volume between the two groups(P＞0.05).The doses of Propofol and Sufentanil in the group D were less than those in the group C,the hospital stay was shorter than that in the group C,the rate of postoperative nausea and vomiting was lower than that in the group C,and the differences were statistically significant(P＜0.05).There were no significant differences in CRP and N at each time point after surgery between the two groups (P＞0.05).The ESR and IL-6 levels at each time point after surgery in the group D were lower than those in the group C,and the differences were statistically significant(P＜0.05).The values of ED,ND,CD and OPR at each time point after surgery in the group D were significantly higher than those in the group C,and the differences were statistically significant(P＜0.01).Conclusion The application of Dexmedetomidine in elderly patients undergoing laparoscopic radical gastrectomy for gastric cancer can significantly reduce the dosage of anesthetic,shorten the hospitalization time,reduce the postoperative inflammatory response,and facilitate postoperative functional recovery.
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