Research on improving the iron-deficiency anemia in rats by Huangqi E-jiao Butie Oral Solution
LIN Jian1，2 ZHANG Wei-hua3，4 LIN Wei1 GONG Xiu-xiu3，4 ZHONG Li-yun1 CHEN Guan-min1，2
1.Fujian Provincial Key Laboratory of Zoonosis Research (Fujian Center for Disease Control and Prevention),Fujian Province,Fuzhou 350001,China;
2.Teaching Base of Fujian Medical University,Fujian Province,Fuzhou 350001,China;
3.Beijing BodyRevivalPharmaceuticalTechnologyDevelopment Co.,Ltd.,Beijing 100088 China;
4.Zhuhai Branch,Beijing Body Revival Pharmaceutical Technology Development Co.,Ltd.,Guangdong Province,Zhuhai519040,China
Abstract：Objective To get known the effect of Huangqi Ejiao Butie Oral Solution in improving iron-deficiency anemia.MethodsSeventy-four rats were selected.The an animal model of anemia using iron-deficiency diet was established.These rat models were divided into the low-,medium-,and high-dose sample groups and low-iron group by random block based on the hemoglobin (Hb)level,3.33 ml/kg BW,6.67 ml/kg BW and 20.0 ml/kg BW,and deionized water for 32-day intragastric administration in turn.The rats'weight,Hb,hematocrit(Hct)and free erythrocyte protoporphyrin (FEP)were observed.Results There was no significant difference in rat body weight in these sample groups compared with low-iron control group(P＞0.05）.The Hb(F=161.156)and Hct(F=78.771)in the three dose groups using Huangqi Ejiao Butie Oral Solution were significantly higher than those in the low-iron control group(P＜0.05）.The value of FEP(F=170.516)was significantly lower compared with that in the low-iron control group,the differences were statistically significant(P＜0.05）.Conclusion Huangqi Ejiao Butie Oral Solution can improve iron-deficiency anemia.
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