Abstract：Objective To investigate the traditional Chinese medicine (TCM)constitution of patients with peptic ulcer and its relationship with Helicobacter pylori(Hp)infection.Methods A total of 169 patients with peptic ulcer treated in our hospital from February 2015 to November 2017 were selected,and the type of the physique of TCM was judged by nine basic constitution classification sub-scales in Classification and determination of TCM constitution,and Hp infection in patients with different TCM constitution was observed.Results In 169 patients with peptic ulcer,the TCM constitution was calm physique,yang-deficiency physique,phlegm-dampness physique,blood stasis physique,specialty physique,qi-deficiency physique,yin-deficiency physique,dampness-heat physique and qi-depression physique,of which yang-deficiency physique was the most,and it accounted for 21.30% (36/169),followed by damp and heat physique,accounting for 15.38%(26/169),while specialty physique was the least,accounting for 0.59%(1/169).There was no significant difference in the positive and negative rate of Hp in peptic ulcer patients with TCM constitution of calm physique,phlegm-dampness physique,blood stasis physique,specialty physique,yin-deficiency physique and qidepression physique (P＞0.05),the positive rate of Hp in patients with peptic ulcer with yang-deficiency physique,qideficiency physique and damp-heat physique constitution were higher than those in negative rate,and the differences were statistically significant(P＜0.05).Conclusion Peptic ulcer patients with yang-deficiency physique are susceptible to Hp infection,and it is of great significance to clarify the type of TCM constitution of patients,and adjust the constitution help to prevent Hp infection and recurrence of peptic ulcer.
周文博;黎明;饶娟. 消化性溃疡患者中医体质调查及其与幽门螺杆菌感染的关系[J]. 中国当代医药, 2018, 25(25): 157-159转163.
ZHOU Wen-bo;LI Ming;RAO Juan. Investigation of the traditional Chinese medicine constitution in patients with peptic ulcer and its relationship with Helicobacter pylori infection. 中国当代医药, 2018, 25(25): 157-159转163.
Scally B，Emberson JR，Spata E，et al.Effects of gastroprotectant drugs for the prevention and treatment of peptic ulcer disease and its complications：a meta-analysis of randomised trials[J].Lancet Gastroenterol Hepatol，2018，3（4）：231-241.
[2]
Take S，Mizuno M，Ishiki K，et al.Seventeen-year effects of eradicating Helicobacter pylori on the prevention of gastric cancer in patients with peptic ulcer;a prospective cohort study[J].J Gastroenterol，2015，50（6）：638-644.
[3]
Thorsen K，Sreide JA，Sreide K.What is the best predictor of mortality in perforated peptic ulcer disease?A population-based，multivariable regression analysis including three clinical scoring systems[J].J Gastrointest Surg，2014，18（7）：1261-1268.
[4]
Melinder C，Udumyan R，Hiyoshi A，et al.Decreased stress resilience in young men significantly increases the risk of subsequent peptic ulcer disease-a prospective study of men in Sweden[J].Aliment Pharmacol Ther，2015，41（10）：1005-1015.
[5]
Chiu PW，Joeng HK，Choi CL，et al.High-dose omeprazole infusion compared with scheduled second-look endoscopy for prevention of peptic ulcer rebleeding：a randomized controlled trial[J].Endoscopy，2016，48（8）：717-722.
京公网安备 11010502046607号