短链脂肪酸与糖尿病肾病关系的研究进展

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摘要

糖尿病肾病是糖尿病的常见并发症之一，也是终末期肾病的常见病因。遗传因素、代谢紊乱、氧化应激、炎症反应等与糖尿病肾病的发生发展密切相关，但其发病机制尚不明确。短链脂肪酸是肠道菌群在宿主肠道内发酵膳食纤维主要的代谢产物，通过激活G 蛋白偶联受体和去乙酰组蛋白受体参与调节食欲、调节糖代谢、调节脂质代谢、减轻炎症反应等一系列代谢过程，从而在糖尿病肾病的发生发展中可能起到关键作用。本文就短链脂肪酸与糖尿病肾病的关系和相关争议展开综述，旨在为了解短链脂肪酸在糖尿病的发生发展中的作用及为糖尿病肾病预防和治疗提供新的思路。

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关键词 ：糖尿病, 糖尿病肾病, 短链脂肪酸, G 蛋白偶联受体

Abstract：

Diabetic kidney disease is one of the most common complications of diabetes mellitus and a common cause of end-stage renal disease.Genetic factors,metabolic disorders,oxidative stress,and inflammatory responses are closely related to the occurrence and development of diabetic kidney disease,but its pathogenesis is still unclear.Short-chain fatty acids are the main metabolites of dietary fiber fermented by intestinal flora in the host intestine.They participate in a series of metabolic processes,such as regulating appetite,regulating glucose metabolism,regulating lipid metabolism,and reducing inflammatory responses by activating G protein-coupled receptors and deacetylhistone receptors,and thus may play a key role in the occurrence and development of diabetic kidney disease.This article discusses the relationship between short-chain fatty acids and diabetic kidney disease and related controversies,in order to provide new ideas for understanding the role of short-chain fatty acids in the occurrence and development of diabetes and the prevention and treatment of diabetic kidney disease.

Key words： Diabetes mellitus Diabetic kidney disease Short-chain fatty acids G protein-coupled receptors

基金资助:

国家级教学质量工程项目（2022JXD209）；
科技部国家重点研发计划项目（2019YFE0110500）；
云南省高层次人才培养支持计划项目（RLMY20200022）；
云南省教育厅科学研究基金项目（2022J0269、2022J0268）；
昆明医科大学研究生创新基金项目（2022S221、2023S260）。

通讯作者: 李俊（1968-），女，白族，云南大理人，博士，主任医师；研究方向：肾间质纤维化。

作者简介: 李莎（1998-），女，汉族，云南玉溪人，硕士；研究方向：肾间质纤维化。

引用本文:

李莎；王美禹；刘勇兰；张迪；周文京；李俊. 短链脂肪酸与糖尿病肾病关系的研究进展[J]. 中国当代医药, 2024, 31(14): 193-198.
LI Sha1 WANG Meiyu2 LIU Yonglan1 ZHANG Di1 ZHOU Wenjing1 LI Jun1. Research progress on the relationship between short-chain fatty acids and diabetic kidney disease. 中国当代医药, 2024, 31(14): 193-198.

链接本文:

https://www.dangdaiyiyao.com/CN/ 或 https://www.dangdaiyiyao.com/CN/Y2024/V31/I14/193

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