Objective To explore the effect of mindfulness behavior training combined with early rehabilitation exercise on disability acceptance of patients with plastic skin grafting after severe upper extremity burn.Methods A total of 60 patients with plastic skin grafting after severe upper extremity burn admitted to the First Affiliated Hospital of Nanchang University from January 2022 to March 2023 were selected as the study objects,and they were divided into control group(30 cases)and observation group (30 cases)according to computer random number grouping method.The control group was received early rehabilitation exercise,and the observation group was received mindfulness behavior training combined with early rehabilitation exercise.The wrist function and ability of daily living,disability acceptance and aesthetic satisfaction scores,anxiety and depression scores and compliance were compared between the two groups.Results After intervention,the scores of Cooney and modified Barthel index (MBI)in two groups were higher than those before intervention,and the scores in the observation group were higher than those in the control group,with statistical significances(P＜0.05).After intervention,the scores of acceptance of disability scale (AODS) and numerical score system (NSS) in two groups were higher than those before intervention,and the scores of observation group were higher than those of the control group,the differences were statistically significant(P＜0.05).After intervention,the scores of self-rating anxiety scale(SAS)and self-rating depression scale (SDS)of the two groups were lower than those before intervention,and the scores of observation group were lower than those of the control group,the differences were statistically significant (P＜0.05).The compliance rate of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion Mindfulness behavior training combined with early rehabilitation exercises can improve the wrist joint function and daily living ability of patients with plastic skin grafting after severe upper limb burns,improve disability acceptance and aesthetic satisfaction,and reduce anxiety and depression.