Meta-analysis of efficacy and safety of indocyanine green fluorescence cholangiography in complex laparoscopic cholecystectomy
WU Linde1 TU Yonglang2▲ GAO Guohua1 LI Gang1
1.Department of Hepatobiliary Surgery,the First Affiliated Hospital of Kunming Medical University,Yunnan Province,Kunming 650032,China;
2.Department of General Surgery,Yunnan Maternal and Child Health Care Hospital,Yunnan Province,Kunming 650051,China
Abstract：Objective To compare the efficacy and safety of indocyanine green (ICG) fluorescence cholangiography combined with laparoscopic cholecystectomy (LC)and conventional LC in the treatment of complicated LC.Methods Through the retrieval database,studies comparing the efficacy of ICG fluorescence cholangiography LC test group and conventional LC control group in complex LC from 2018 to 2022 were retrieved.After the quality of the included literature was evaluated and the relevant research data were extracted,RevMan Manager 5.4 was used for meta-analysis.Results A total of 14 articles were included in this study,including 1 116 cases.The analysis showed that compared with the conventional LC treatment group,the ICG combined LC group had shorter operation time(MD=-24.37,95%CI:-32.87 to-15.86)and less intraoperative blood loss(MD=-11.36,95%CI:-15.34 to-7.37),shorter time to recognize biliary structure(MD=-16.79,95%CI:-31.00 to-2.58),shorter postoperative hospital stay (MD=-0.61,95%CI:-1.13 to-0.09),shorter recovery time of anal exhaust function(MD=-2.61,95%CI:-5.40 to-0.17),lower total incidence of postoperative complications(OR=0.57,95%CI:0.16 to-0.44),and less hospitalization costs(MD=-1 549.69,95%CI:-2 647.34 to-452.04).There were no significant differences in postoperative drainage tube removal time and intraoperative conversion rate between the two groups (P＞0.05).Conclusion ICG cholangiography is safe and effective in LC for complex gallbladder diseases,which can reduce the risk of bile duct injury.
Pucher PH，Brunt LM，Davies N，et al.Outcome trends and safety measures after 30 years of laparoscopic cholecystectomy：a systematic review and pooled data analysis[J].Surg Endosc，2018，32（5）：2175-2183.
Ishizawa T，Tamura S，Masuda K，et al.Intraoperative fluorescent cholangiography using indocyanine green：a biliary road map for safe surgery[J].J Am Coll Surg，2009，208（1）：e1-e4.
[6]
Ishizawa T，Bandai Y，Kokudo N.Fluorescent cholangiography using indocyanine green for laparoscopic cholecystectomy：an initial experience[J].Arch Surg，2009，144（4）：381-382.
京公网安备 11010502046607号