Abstract：Spinal cord injury is a common traumatic disease in spinal surgery,often accompanied by severe functional impairment of limbs below the injury level,and even life-threatening respiratory complications.Extensive research data from both domestic and international sources have investigated the pathological and regenerative mechanisms of spinal cord injury.Traditional Chinese medicine (TCM)has a long history of treating spinal cord injury,with its independent dialectical thinking mode,emphasis on individualized treatment,and irreplaceable role of herbal medicine and acupuncture therapy in the treatment of spinal cord injury.This article systematically reviews the pathogenesis of spinal cord injury,from ancient understanding to modern clinical and experimental research,summarizes the etiology and pathogenesis of spinal cord injury,TCM diagnostic key points,various treatment mechanisms and current status,and summarizes the modernized treatment of spinal cord injury in TCM,aiming to explore new ideas for the future development of TCM-based treatment for spinal cord injury.
魏延冕1； 周玫彤2. 脊髓损伤的中医现代化治疗研究进展[J]. 中国当代医药, 2024, 31(13): 175-179.
WEI Yanmian1 ZHOU Meitong2. Research progress on modernized treatment of spinal cord injury in traditional chinese medicine. 中国当代医药, 2024, 31(13): 175-179.
Hara M，Kobayakawa K，Ohkawa Y，et al.Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin -N-cadherin pathway after spinal cord injury[J].Nat Med，2017，23（7）：818-828.
Dietz V，Fouad K.Restoration of sensorimotor functions after spinal cord injury[J].Brain，2014，137（Pt 3）：654-667.
[9]
Gensel JC，Zhang B.Macrophage activation and its role in repair and pathology after spinal cord injury[J].Brain Res，2015，1619：1-11.
[10]
Zhao C，Rao JS，Duan H，et al.Chronic spinal cord injury repair by NT3-chitosan only occurs after clearance of the lesion scar[J].Signal Transduct Target Ther，2022，7（1）：184.
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