Abstract：Objective To investigate the effect of low-dose heparin sodium combined with mechanical assisted expectoration in the treatment of bronchopneumonia in children.Methods The clinical data of 100 children with bronchopneumonia who were treated in the Department of Pediatrics,Pingxiang People's Hospital,from April 2018 to November 2022 were retrospectively analyzed.According to the different treatment methods,they were divided into the conventional group (34 cases),heparin sodium group (33 cases),and combination group (33 cases).The conventional group was treated with symptomatic treatment such as fluid replacement,anti-infection,and relieving cough.The heparin sodium group was treated with low-dose heparin sodium,and the combination group was treated with mechanical expectoration on the basis of the above.The disappearance time of clinical symptoms,hospital stay and clinical efficacy of the three groups were compared.Results The cough disappearance time,lung rales disappearance time,hospitalization time and antipyretic time in the combination group were shorter than those in the conventional group and the heparin sodium group,and the cough disappearance time,lung rales disappearance time,hospitalization time and antipyretic time in the heparin sodium group were shorter than those in the conventional group,and the differences were statistically significant(P＜0.05).After 7 days of treatment,the effective rate of the combination group was higher than that of the conventional group,and the difference was statistically significant (P ＜0.017).After treatment,the levels of partial pressure of oxygen in arterial blood (PaO2),oxygenation index(OI)and arterial oxygen saturation(SpO2)in the three groups were higher than those before treatment,and the level of partial pressure of carbon dioxide in arterial blood (PaCO2) in the three groups were lower than those before treatment,and the levels of PaO2,OI and SpO2 in the combination group were higher than those in the heparin sodium group and the conventional group,and the level of PaCO2 in the heparin sodium group was lower than that in the heparin sodium group and the conventional group,the levels of PaO2,OI and SpO2 in the heparin sodium group were higher than those in the conventional group,and the level of PaCO2 in the heparin sodium group was lower than that in the conventional group,and the differences were statistically significant(P＜0.05).After treatment,the white blood cell count and neutrophil percentage levels of the three groups were lower than those before treatment,the white blood cell count and neutrophil percentage level of the combination group were lower than those of the heparin sodium group and the conventional group,and the white blood cell count and neutrophil level of the heparin sodium group were lower than those of the conventional group,and the differences were statistically significant(P＜0.05).Conclusion Low-dose heparin sodium combined with mechanical-assisted expectoration is effective in treating children with bronchopneumonia,which can effectively improve clinical symptoms and shorten treatment time.
万芳； 黄 斌； 陈思. 小剂量肝素钠联合机械辅助排痰治疗小儿支气管肺炎的效果[J]. 中国当代医药, 2024, 31(13): 49-53.
WAN Fang HUANG Bin CHEN Si. Effect of low-dose heparin sodium combined with mechanical assisted expectoration in the treatment of bronchopneumonia in children. 中国当代医药, 2024, 31(13): 49-53.
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