Abstract：Objective To study and analyze the causes of anastomotic leakage after laparoscopic surgery for colorectal cancer,and explore corresponding preventive measures.Methods A total of 676 patients with colorectal cancer who underwent laparoscopic surgery at the Department of Gastroenterology Surgery,Liuzhou People's Hospital from January 2018 to December 2022 were selected as the study objects.They were divided into a study group (49 cases with anastomotic leakage)and a control group (627 cases without anastomotic leakage)based on whether they experienced anastomotic leakage after surgery.Retrospective analysis was conducted on the clinical data of two groups of cases,and logistic regression analysis was used to analyze the influencing factors of anastomotic fistula after laparoscopic surgery for colorectal cancer.Results The results of single factor analysis showed that there were significant differences between the study group and the control group in gender,age,body mass index,diabetes,preoperative serum albumin,and operation time(P＜0.05).The results of multiple factor analysis suggest that males (β=0.335,OR=2.561,95%CI:1.489-3.082),age ≥60 years old (β=0.361,OR=2.457,95%CI: 1.193-3.107),body mass index ≥24.9 kg/m2 (β=0.329,OR=2.379,95%CI:1.140-3.278),combined with diabetes(β=0.328,OR=2.369,95%CI: 1.207-3.114),preoperative serum albumin＜35 g/L (β=0.357,OR=2.418,95%CI:1.245-3.098),surgery time ≥3.5 hours(β=0.348,OR=2.406,95%CI:1.352-3.069)were the risk factors for anastomotic fistula after laparoscopic colorectal cancer surgery (P＜0.05).Conclusion Patients with colorectal cancer after laparoscopic surgery are affected by gender,age,body mass index,diabetes and other factors,and are prone to anastomotic leakage.
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