Clinical studies of the adverse reactions of Propafenone mostly ignore gastrointestinal reactions,and there are no reports of adverse events such as severe constipation or mixed hemorrhoid incarceration.A case of arrhythmia was reported in this paper.The patient was treated with Propafenone Hydrochloride Tablets for three times,and the symptoms of constipation were repeated.According to the correlation between the patient's clinical manifestations and the duration of medication,it was considered that Propafenone Hydrochloride Tablets caused severe constipation and mixed hemorrhoid incarceration.It is suggested that the clinical application of Propafenone Hydrochloride Tablets should be started with a small dose according to the instructions,and the patients should be informed of the possible adverse reactions.If the adverse reactions still occur and can not be tolerated,the drug should be stopped in time or added with traditional Chinese medicine.