Efficacy observation of different cut-off values of tumor abnormal protein in screening lung cancer
NONG Xueping1 HUANG Jianhua2▲ LIU Chengying1
1. Department of Pathology, Jiangxi Chest Hospital, Jiangxi Province, Nanchang 330006, China
2. Department of Respiratory and Critical Care Medicine, Jiangxi Chest Hospital, Jiangxi Province, Nanchang 330006, China
Abstract：Objective To explore the efficacy of different cut-off values of tumor abnormal protein (TAP) in screening lung cancer. Methods A total of 66 lung cancer patients and 66 non-lung cancer patients admitted to Jiangxi Chest Hospital from January 2021 to January 2022 were selected as the research objects. The area difference of TAP aggregate between lung cancer patients and non-lung cancer patients was calculated to determine whether TAP can be used to diagnose lung cancer. The optimal cut-off value of TAP was obtained by drawing the ROC curve to diagnose lung cancer and determine the diagnostic efficiency. The diagnostic efficiency was compared with the clinical common TAP normal reference range (＜121 μm2). Results TAP condensed area of lung cancer group is greater than the lung cancer group, and the difference was statistically significant (P＜0.05). By drawing the ROC curve, the highest cut-off value＞170 μm2 was determined, and the diagnostic efficacy was compared with the normal reference range of TAP (＜121 μm2). The results showed that there were no significant differences in the positive detection rate, sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic coincidence rate between the two groups (P＞0.05). Conclusion Different cut-off values of TAP are used to screen suspected lung cancer patients, and the screening effect is better with the cut-off value of 170 μm2, which is worthy of clinical application.
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