Ankle sprain is one of the most common sports injury in clinic.The treatment of acute sprain is very important.If it is not handled properly,it is easy to leave chronic pain,ankle instability and habitual sprain.In clinical treatment,traditional Chinese medicine has summarized the treatment principle of"emphasizing both muscles and bones,and treating both internal and external diseases",established a dialectical approach of"promoting blood circulation and resolving stasis,promoting qi circulation and unblocking collaterals",including "manipulation,fixation,medicine,acupuncture and moxibustion,practice",etc.Western medicine follows the"RICE"principle,which is the standard strategy for the treatment of acute ankle sprain (AAS)advocated by the American Academy of Orthopaedic Surgeons (AAOS),including "rest,ice,compression and elevation".The treatment methods are rich and diverse,but lack systematicity.This article reviews the traditional Chinese and western medicine treatment plans for acute ankle sprain,and explores the cutting-edge knowledge of the multidisciplinary and multi means comprehensive treatment of AAS by combining Chinese and western medicine,providing valuable reference for clinical diagnosis,treatment and rehabilitation.