Objective To investigate the effect of Glucosamine Hydrochloride combined with Celecoxib in the treatment of knee osteoarthritis and its effect on inflammatory factors.Methods A total of 62 patients with knee osteoarthritis treated in Jiangning Hospital Affiliated to Nanjing Medical University from June 2020 to June 2021 were selected as the research objects.They were divided into routine group and observation group by random number table method,with 31 cases in each group.The conventional group was treated with Celecoxib,and the observation group was treated with Glucosamine Hydrochloride on the basis of the conventional group.The effects of the two groups were observed after 8 weeks of continuous treatment.The severity Index of osteoarthritis(ISOA)score,C-reactive protein(CRP)and clinical efficacy of the two groups were compared,and the adverse reactions during treatment were recorded.Results There were no significant differences in the ISOA score and CRP between the two groups before treatment (P＞0.05).The ISOA score and CRP of the two groups after treatment were lower than those before treatment,and the differences were statistically significant(P＜0.05).The ISOA score and CRP of the observation group after treatment were lower than those of the conventional group,and the differences were statistically significant(P＜0.05).The total effective rate of the observation group was higher than that of the routine group,and the difference was statistically significant (P＜0.05).The total incidence of adverse reactions in the observation group was lower than that in the routine group,and the difference was statistically significant (P ＜0.05).Conclusion Glucosamine Hydrochloride combined with Celecoxib in the treatment of knee osteoarthritis can reduce the severity score of knee osteoarthritis,improve the clinical efficacy and reduce the incidence of adverse reactions.