Objective To explore the diagnostic value of liver stiffness measurement (LSM),aspartate aminotransferase-to-platelet ratio index (APRI)and liver fibrosis index based on 4 factors (FIB-4)in children with liver fibrosis.Methods A total of 90 children with liver disease treated in Ganzhou Maternal and Child Health Hospital of Jiangxi Province from September 2020 to November 2021 were selected as the research objects.According to the degree of fibrosis,they were divided into the mild liver fibrosis group (52 cases)and the severe liver fibrosis group (38 cases).The LSM of the children was detected,and APRI and FIB-4 were calculated through the serological diagnostic model.The critical values of LSM,APRI,FIB-4 and the area under the receiver operating characteristic (ROC)curve were calculated by analyzing the ROC.The diagnostic value of LSM,APRI and FIB-4 for liver disease cirrhosis in each group were evaluated,and the correlation between LSM and APRI and FIB-4 were analyzed.Results The LSM,APRI and FIB-4 levels in the severe hepatic fibrosis group were higher than those in the mild hepatic fibrosis group,the differences were statistically significant (P＜0.05).The ROC analysis results showed that the cut-off values of LSM,APRI and FIB-4 for the diagnosis of liver fibrosis were 8.355,0.975 and 0.075 respectively,and the area under the curve was 0.923,0.934 and 0.952 respectively.The area under the curve of combined diagnosis was higher than that of single diagnosis.Correlation analysis showed that LSM were positively correlated with APRI (r=0.673,P＜0.001) and FIB-4 (r=0.582,P＜0.001).Conclusion LSM,APRI and FIB-4 are valuable in the diagnosis of hepatic fibrosis in children with liver diseases.