Clinical significance of serum N-terminal pro B-type brain natriuretic peptide,prealbumin,interleukin-32 and interleukin-6 in early diagnosis and prognosis of acute myocardial infarction with pulmonary infection
FENG Xujun
Department of Respiratory Medicine,Jiujiang First People's Hospital,Jiangxi Province,Jiujiang 332000,China
Abstract：Objective To investigate the clinical significance of serum N-terminal pro B-type brain natriuretic peptide(NT-proBNP),prealbumin (PA),interleukin-32 (IL-32)and interleukin-6 (IL-6)in the early diagnosis and prognosis of acute myocardial infarction (AMI) with pulmonary infection.Methods A total of 63 patients with AMI with pulmonary infection treated in Jiujiang First People's Hospital from July to December 2020 were selected as the observation group,and 32 healthy people who underwent physical examination in the same period were selected as the control group.The levels of NT-proBNP,PA,IL-32 and IL-6 in the observation group and the control group were compared,and the diagnostic results of each index alone and combined detection for AMI with pulmonary infection were analyzed.According to the occurrence of adverse cardiac events,the patients in the observation group were divided into good prognosis group (46 cases) and poor prognosis group (17 cases).The levels of NT-proBNP,PA,IL-32 and IL-6 in the good prognosis group and the poor prognosis group were compared.Results The levels of NT-proBNP,IL-32 and IL-6 in the observation group were higher than those in the control group,and the level of PA in the observation group was lower than that in the control group,and the differences were statistically significant(P＜0.05).The area under curve(AUC)of NT-proBNP,IL-32 and IL-6 combined detection in the diagnosis of AMI with pulmonary infection was 0.930 (95%CI=0.886-0.963),the sensitivity was 96.20%,and the specificity was 81.21%.The sensitivity of combined detection was higher than that of single index detection.The levels of NT-proBNP,IL-32 and IL-6 in the poor prognosis group were higher than those in the good prognosis group,and the level of PA was lower than that in the good prognosis group,and the differences were statistically significant (P＜0.05).Conclusion The combined diagnosis of NT-proBNP,PA,IL-32 and IL-6 can improve the diagnostic value of AMI with pulmonary infection,and can effectively evaluate the prognosis and guide the treatment.
冯徐俊. 血清氨基末端B 型脑钠肽前体、前白蛋白、白细胞介素-32、白细胞介素-6 在伴肺部感染急性心肌梗死早期诊断和预后评估中的临床意义[J]. 中国当代医药, 2022, 29(31): 53-56.
FENG Xujun. Clinical significance of serum N-terminal pro B-type brain natriuretic peptide,prealbumin,interleukin-32 and interleukin-6 in early diagnosis and prognosis of acute myocardial infarction with pulmonary infection. 中国当代医药, 2022, 29(31): 53-56.
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