The nerve protective effect of urokinase-type plasminogen activator after cerebral ischemia injury
XU Yuwen1 LI Mengyuan1 DENG Yun1 XUE Min1 LU Li
1.Lanzhou University Second Hospital,Gansu Province,Lanzhou 730030,China;
2.Institute of Pharmacology,School of Basic Medical Sciences,Lanzhou University,Gansu Province,Lanzhou 730030,China
Abstract：Urokinase-type plasminogen activator (uPA) is a serine proteolytic,which plays a role in the occurrence and development of tumors and other diseases,mainly related to cell differentiation,migration,tissue reconstruction and degradation of extracellular matrix.In the past,many scholars focus on uPA's effects in the growth of central nervous system and many diseases such as cancers.In recent years,there has been some research progress of uPA in the treatment of cerebral ischemia injury.Studies suggest that uPA has a neuroprotective effect after ischemia，modulating synaptic plasticity,extending and regenerating the damaged axons,promoting the repair and regeneration of neurons and improving ischemic sequela,which gives hope to the treatment of ischemia sequela.However,the exact mechanism by which it exerts its neuroprotective effect is unclear.These factors bring challenges to the application of uPA and related drugs in the field of neuroprotection after cerebral ischemia.
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