银杏叶提取物联合倍他司汀在急性单侧前庭功能减低患者中的应用效果

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摘要

目的探讨银杏叶提取物联合甲磺酸倍他司汀治疗急性单侧前庭功能减低（UVH）的临床效果。方法选取2020年10月至2021年4月就诊于大连市第三人民医院耳鼻喉科及眩晕门诊的60例急性UVH患者作为研究对象，采用随机数字表法将其分为观察组与对照组，每组各30例。对照组患者在常规前庭康复治疗的同时口服甲磺酸倍他司汀片治疗，观察组患者在对照组的基础上加用银杏叶提取物片口服治疗。两组患者均连续治疗1个月，比较两组患者治疗前后的头晕评价量表（DHI）评分、冷热试验结果及治疗期间不良反应发生情况。结果两组患者治疗前的半规管轻瘫指数（UW）值及DHI评分比较，差异无统计学意义（P＞0.05）；两组患者治疗后的UW值及DHI评分均低于治疗前，差异有统计学意义（P<0.05）；治疗后，观察组患者的DHI评分及UW值低于对照组，差异有统计学意义（P<0.05）。两组患者的不良反应总发生率比较，差异无统计学意义（P＞0.05）。结论银杏叶提取物与甲磺酸倍他司汀联合治疗可以更显著改善急性UVH的患者的头晕症状，治疗无明显不良反应，安全性较高。

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关键词 ：单侧前庭功能减低, 银杏叶提取物, 倍他司汀, 冷热试验

Abstract：

Objective To investigate the clinical efficacy of Ginkgo Biloba Extract combined with Betastine in the treatment of acute unilateral vestibular hysfunction(UVH).Methods A total of 60 patients with acute UVH who were admitted to the Department of Otolaryngology and Vertigo Clinic of the Dalian Third People′s Hospital from October 2020 to April 2021 were selected as the study subjects.They were divided into observation group and control group by random number table method,30 cases in each group.Patients in the control group were treated with Betahistine Mesylate Tablets and conventional vestibular rehabilitation,while patients in the observation group were treated with Ginkgo Biloba Extract Tablets on the basis of the control group.Both groups were treated for 1 month.The scores of dizziness rating scale(DHI),cold and heat test results and adverse reactions during treatment were compared between the two groups before and after treatment.Results There were no significant differences in semicircular canal paresis index(UW)and DHI score between the two groups before treatment(P>0.05).The UW and DHI scores of the two groups after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).After treatment,the DHI score and UW value of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The combined treatment of Ginkgo Biloba Extract and Betastine can significantly improve the dizziness symptoms of patients with acute unilateral vestibular dysfunction,with no obvious adverse reactions and high safety.

Key words： Unilateral vertibular hypofunction Ginkgo Bilobal Extract Betahistine Caloric test

基金资助:辽宁省大连市医学科研计划项目（2011010）

引用本文:

孙贵虎;刘晓阳;杨星昱. 银杏叶提取物联合倍他司汀在急性单侧前庭功能减低患者中的应用效果[J]. 中国当代医药, 2022, 29(29): 105-108.
SUN Guihu1 Liu Xiaoyang2▲YANG Xingyu2. Application effect of Ginkgo Biloba Extract combined with Betastine in the treatment of acute unilateral vestibular dysfunction. 中国当代医药, 2022, 29(29): 105-108.

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https://www.dangdaiyiyao.com/CN/ 或 https://www.dangdaiyiyao.com/CN/Y2022/V29/I29/105

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