Effect of Jiawei Tongluo Recipe on patients with acute cerebral infarction of Qi deficiency and blood stasis combined with Yin deficiency
LI Zhaosheng1 NA Lisha2▲ JIA Qian1 QU Na2 GUAN Yaxin
1.Department of Neurology,Hongqi Hospital Affiliated to Mudanjiang Medical College,Heilongjiang Province,Mudanjiang 157011,China;
2.Department of Pharmacy,Hongqi Hospital Affiliated to Mudanjiang Medical College,Heilongjiang Province,Mudanjiang 157011,China
Abstract：Objective To investigate the effect of Jiawei Tongluo Recipe on patients with acute cerebral infarction of Qi deficiency and blood stasis combined with Yin deficiency,and the effect of Jiawei Tongluo Recipe on patients with mercaptopyruvate thiotransferase-3 (3-MST),vascular endothelial growth factor (VEGF),angiotensin Ⅱ(AngⅡ),National Institutes of Health Stroke scale (NIHSS) and transcranial Doppler (TCD) indicators.Methods A total of 100 patients with acute cerebral infarction of Qi deficiency and blood stasis combined with Yin deficiency admitted to Hongqi Hospital Affiliated to Mudanjiang Medical University from January to December 2021 were selected as the research objects.They were divided into observation group and control group by random number table method,with 50 cases in each group.The patients in the observation group were treated with Jiawei Tongluo Recipe,while the patients in the control group were treated with conventional Western medicine.The NIHSS scores,the levels of 3-MST,AngⅡand VEGF before and after treatment were compared between the two groups.The levels of TCD indexes before and after treatment were compared between the two groups.Results Before treatment,there were no significant differences in serum 3-MST levels between the two groups (P＞0.05).The serum 3-MST level of the observation group after treatment was higher than that of the control group,and the difference was statistically significant (P＜0.05).There were no significant differences in serum VEGF and AngⅡlevel between the two groups before treatment (P＞0.05).The serum VEGF level of the observation group after treatment was higher than that of the control group,the AngⅡlevel of the observation group after treatment was lower than that of the control group,and the difference was statistically significant (P＜0.05).There was no significant difference in NIHSS score between the two groups before treatment (P＞0.05).The NIHSS score of the observation group after treatment was lower than that of the control group,and the difference was statistically significant (P＜0.05).Before treatment,there were no significant differences in blood flow spectrum morphology (Vs),mean blood flow velocity (Vm) and pulsitility index (PI) between the two groups (P＞0.05).After treatment,the Vs and Vm levels of the observation group were lower than those of the control group,and PI of the observation group was higher than that of the control group,and the differences were statistically significant (P＜0.05).Conclusion Jiawei Tongluo Recipe has obvious effect on on patients with acute cerebral infarction of Qi deficiency and blood stasis combined with Yin deficiency.It can effectively regulate and establish cerebral collateral compensatory vessels and further control various serum levels.
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