Objective To establish the high performance liquid chromatograghy method for the content determination of Geniposide in Mongolian medicine Ganlu Jiangtang Pills.Methods The chromatographic column was SHIMADZU Shim-pack GIST C18(250 mm×4.6 mm,5 μm),the mobile phase was acetonitrile-water(15∶85,V/V),the flow rate was 0.8 ml/min,detection wavelength was 238 nm,the column temperature was 30℃,and the injection volume was 10 μl.Results Geniposide showed a good linearity in the range of 19.69-78.77 μg/ml(r=0.999 8,n=14).The average recovery was 93.87% with RSD of 1.52%(n=9).The RSD of precision and stability were 0.15% and 0.74%.The average content of 2 batches samples was 5.85 mg/g，with RSD of 1.66%.Conclusion The method is accurate,strong specificity and reproducible which can be used for the quantitation control of Ganlu Jiangtang Pills.