Application effect of Acetylcysteine for inhalation combined with Budesonide for inhalation in lung cancer patients with lower pulmonary function before and after surgery
OUYANG Zhi-cheng LIU Ping-xiang DONG Li-min
Department of Respiratory Medicine,Pingxiang People′s Hospital,Jiangxi Province,Pingxiang 337000,China
Abstract: Objective To investigate the application effect of Acetylcysteine for inhalation combined with Budesonide for inhalation in lung cancer patients with lower pulmonary function before and after surgery.Methods A total of 40 lung cancer patients with lower pulmonary function who admitted in Pingxiang People′s Hospital from January 2018 to December 2019 were selected and divided into two groups according to random number table,20 cases in each group.The control group was given Budesonide for inhalation,and experimental group added Acetylcysteine.The pulmonary function (forced expiratory volume in first second [FEV1],forced expiratory volume in first second/forced vital capacity[FEV1/FVC],minute ventilation volume [MVV]),indexes of blood gas analysis (arterial partial pressure of oxygen [PaO2],arterial partial pressure of carbon dioxide [PaCO2]),hospital stays,use intensity and usage days of antibiotics,and complications were compared between two groups.Results The levels of FEV1 and FEV1/FVC in experimental group were higher than those in control group after discharge for 1 month(P<0.05).The level of PaO2 in experimental group was higher than that in control group after discharge for 1 month,the level of PaCO2 in experimental group was lower than that in control group,the hospital stays and usage days of antibiotics in experimental group were shorter than those in control group,and the use intensity of antibiotics in experimental group was lower than that in control group,the differences were statistically significant (P<0.05).There was no statistical difference in the incidence of complications between two groups (P>0.05).Conclusion Acetylcysteine inhalation combined with Budesonide inhalation in lung cancer patients with lower pulmonary function before and after surgery can improve pulmonary function and indexes of blood gas analysis,shorten hospital stays,and reduce the use of antibiotics,which has high safety and is worthy of clinical promotion.
欧阳志成 刘平香 董利民. 吸入用乙酰半胱氨酸联合吸入布地奈德在低肺功能肺癌患者手术前后的应用效果[J]. 中国当代医药, 2020, 27(32): 59-61.
OUYANG Zhi-cheng LIU Ping-xiang DONG Li-min. Application effect of Acetylcysteine for inhalation combined with Budesonide for inhalation in lung cancer patients with lower pulmonary function before and after surgery. 中国当代医药, 2020, 27(32): 59-61.