Abstract： Objective To observe the clinical effect of Wuzhi Dripping Pills combined with Entecavir in treatment of chronic hepatitis B (CHB).Methods A total of 80 patients with CHB who admitted to Ganzhou Fifth People′s Hospital from December 2015 to December 2019 were selected and divided into two groups according to random number table method,40 cases in each group.The control group was given Entecavir and Interferon,and research group added Wuzhi Dripping Pills.The total effective rate,TCM syndrome score,liver function （alanine transaminase [ALT],aspartic transaminase [AST],γ-glutamyl transpeptidase [GGT]）,and adverse reactions were compared between two groups.Results The total curative effective rate of patients in research group was higher than that in the control group,with statistical difference (P<0.05).The scores of primary symptom and secondary symptom in research group were lower than those in control group after treatment (P<0.05).The levels of ALT,AST and GGT of patients in research group were lower than those in control group after treatment,with statistical differences (P<0.05).There was no statistically significant difference between the two groups in the total incidence of adverse reactions (P＞0.05).Conclusion Wuzhi Dripping Pills combined with Entecavir in treatment of CHB has significant effects it can improve clinical symptoms and liver function,and have higher safety,which is worthy of clinical promotion and application.
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