When anti-infective drugs and anti-epileptic drugs are treated simultaneously, on the one hand, attention should be paid to the possible epileptogenic adverse reactions of antiinfective drugs, and on the other hand, attention should be paid to the interaction between antiinfective drugs and antiepileptic drugs. In this paper, clinical pharmacists provided pharmaceutical care for a child patient with intracranial infection complicated with epilepsy for many times.Including the reorganization of medical orders to analyze the cause of epilepsy in children. It is considered that the cause of poor epilepsy control may be the interaction between Meropenem and Sodium Valproate resulting in the reduction of sodium valproate plasma concentration. The clinical characteristics of the interaction were summarized by literature review. Combined with the pathophysiological characteristics of the children, the epileptogenic nature of anti-infective drugs, the adverse reactions of anti-epileptic drugs and many other factors, to assist doctors to re-formulate anti-infective and anti-epileptic treatment plans. Finally, the infection and epilepsy symptoms of children are effectively controlled. The pharmaceutical care provided by clinical pharmacists throughout the treatment of children not only ensures the safety and effectiveness of the treatment of children, but also provides a reference for the formulation of drug treatment plan for such patients.