益生菌辅助盐酸米诺环素治疗中度慢性牙周炎的效果

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摘要目的探究益生菌辅助盐酸米诺环素治疗中度慢性牙周炎的效果。方法选取2021年4月至2022年3月赣州市妇幼保健院收治的90 例中度慢性牙周炎患者为研究对象，按照随机数字表法分为对照组和观察组，每组各45 例。对照组采用盐酸米诺环素进行治疗，观察组则采用益生菌辅助盐酸米诺环素治疗。比较两组的临床治疗效果、治疗前后的口腔健康情况[口腔健康评估量表（OHAT）评分及附着丧失（CAL）、牙龈指数（GI）、探诊深度（PD）、菌斑指数（PLI）及牙龈出血指数（SBI）]及局部炎症反应指标[龈沟液肿瘤坏死因子-α（TNF-α）、白介素-6（IL-6）及白介素-8（IL-8）]。结果观察组的治疗总有效率高于对照组，差异有统计学意义（P＜0.05）。两组治疗前的OHAT评分比较，差异无统计意义（P＞0.05）；观察组治疗后的OHAT 评分低于对照组，差异有统计学意义（P＜0.05）。治疗前两组患者的CAL、GI、PD、PLI 及SBI 比较，差异无统计意义（P＞0.05）；治疗后观察组的CAL、GI、PD、PLI 及SBI低于对照组，差异有统计学意义（P＜0.05）。治疗前两组的龈沟液炎症指标比较，差异无统计意义（P＞0.05）；治疗后，观察组的TNF-α、IL-6、IL-8 水平低于对照组，差异有统计学意义（P＜0.05）。结论益生菌辅助盐酸米诺环素在中度慢性牙周炎患者中的应用效果较好，且可显著改善患者的口腔健康及局部炎症反应，因此在中度慢性牙周炎患者中的应用价值较高。

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关键词 ：益生菌, 盐酸米诺环素, 慢性牙周炎, 临床效果, 口腔健康, 局部炎症反应

Abstract：Objective To explore the effect of Probiotic assisted Minocycline Hydrochloride on moderate chronic periodontitis. Methods A total of 90 patients with moderate chronic periodontitis admitted to Maternal and Child Health Care Hospital of Ganzhou City from April 2021 to March 2022 were selected as the research objects and divided into control group and observation group according to the random number table method, with 45 cases in each group. The control group were treated with Minocycline Hydrochloride, the observation group were treated with Probiotic assisted Minocycline Hydrochloride. The clinical treatment effect, oral health (scores of oral health assessment tool [OHAT],clinical attachment loss [CAL], gingival index [GI], probing depth [PD], plaque index [PLI], sulcus bleeding index[SBI])and local inflammatory reaction indexes (gingival crevicular fluid tumor necrosis factor-α [TNF-α], interleukin-6 [IL-6]and interleukin-8 [IL-8]) before and after treatment were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant(P<0.05). There was no significant difference in OHAT score between the two groups before treatment (P>0.05). The OHAT score of the observation group after treatment was lower than that of the control group, and the difference was statistically significant (P<0.05). Before treatment, there was no significant difference in CAL, GI, PD, PLI and SBI between the two groups (P>0.05). After treatment, CAL, GI, PD, PLI and SBI in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). Before treatment, there was no significant difference in gingival crevicular fluid inflammation index between the two groups (P>0.05). After treatment,the levels of TNF-α, IL-6 and IL-8 in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). Conclusion The application effect of Probiotic assisted Minocycline Hydrochloride in patients with chronic periodontitis is better, and it can significantly improve the oral health and local inflammatory reaction, so its application value in the patients with chronic periodontitis is higher.

Key words： Probiotic Minocycline hydrochloride Chronic periodontitis Clinical effect Oral health Local inflammatory reaction

基金资助:江西省卫生健康委科技计划项目（202212350）

引用本文:

邹娟；曾志梅. 益生菌辅助盐酸米诺环素治疗中度慢性牙周炎的效果[J]. 中国当代医药, 2022, 29(27): 118-121转125.
ZOU Juan ZENG Zhimei. Effect of Probiotics assisted Minocycline Hydrochloride in patients with moderate chronic periodontitis. 中国当代医药, 2022, 29(27): 118-121转125.

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https://www.dangdaiyiyao.com/CN/ 或 https://www.dangdaiyiyao.com/CN/Y2022/V29/I27/118

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